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  Tracking the neurodegenerative gradient after spinal cord injury

Azzarito, M., Seif, M., Kyathanahally, S., Curt, A., & Freund, P. (2020). Tracking the neurodegenerative gradient after spinal cord injury. NeuroImage: Clinical, 26: 102221. doi:10.1016/j.nicl.2020.102221.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0005-BF9B-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-CFCA-7
Genre: Zeitschriftenartikel

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 Urheber:
Azzarito, Michela1, Autor
Seif, Maryam1, Autor
Kyathanahally, Sreenath1, Autor
Curt, Armin1, Autor
Freund, Patrick1, 2, 3, 4, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              

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Schlagwörter: Spinal cord injury; MRI; Volumetric MRI; MT
 Zusammenfassung: Objective

To quantify neurodegenerative changes along the cervical spinal cord rostral to a spinal cord injury (SCI) by means of quantitative MRI (qMRI) and to determine its relationship with clinical impairment.

Methods

Thirty chronic SCI patients (15 tetraplegics and 15 paraplegics) and 23 healthy controls underwent a high-resolution T1-weighted and myelin-sensitive magnetization transfer (MT) MRI. We assessed macro- and microstructural changes along the cervical cord from levels C1 to C4, calculating cross-sectional spinal cord area, its anterior-posterior and left-right width and myelin content (i.e. MT). Regression analysis determined associations between qMRI parameters and clinical impairment.

Results

In SCI patients, cord area decreased by 2.67 mm2 (p=0.004) and left-right width decreased by 0.35 mm (p=0.002) per level in caudal direction when compared to the healthy controls. This gradient of neurodegeneration was greater in tetraplegic than paraplegics in the cord area (by 3.28 mm2, p=0.011), left-right width (by 0.36 mm, p=0.03), and MT (by 0.13%, p=0.04), but independant of lesion severity (p>0.05). Higher lesion level was associated with greater magnitudes of neurodegeneration. Greater loss in myelin content in the dorsal columns and spinothalamic tract was associated with worse light touch (p=0.016) and pin prick score (p=0.024), respectively.

Conclusions

A gradient of neurodegeneration is evident in the high cervical cord remote from a SCI. Tract-specific associations with appropriate clinical outcomes highlight that remote neurodegenerative changes are clinically eloquent. Monitoring the neurodegenerative gradient could be used to track treatment effects of regenerative and neuroprotective agents, both in trials targeting cervical and thoracic SCI patients.

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Sprache(n): eng - English
 Datum: 2020-01-212019-10-112020-02-172020-02-25
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.nicl.2020.102221
PMID: 32145681
PMC: PMC7058923
Anderer: epub 2020
 Art des Abschluß: -

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Projektinformation

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Projektname : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : INSPIRED project
Förderorganisation : Wings for Life, Austria
Projektname : -
Grant ID : PCEFP3_181362
Förderprogramm : SNF Eccellenza Professorial Fellowship Grant
Förderorganisation : Swiss National Science Foundation (SNSF)
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : Understanding the mechanisms of atrophy associated with spinal cord injury: the application of MRI-based in vivo histology and ex vivo histology / hMRIofSC
Grant ID : 32NE30_173678
Förderprogramm : ERA-NET NEURON
Förderorganisation : European Commission (EC)

Quelle 1

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Titel: NeuroImage: Clinical
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: - Band / Heft: 26 Artikelnummer: 102221 Start- / Endseite: - Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582