English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Short-term modulation of the lesioned language network

Hartwigsen, G., Stockert, A., Charpentier, L., Wawrzyniak, M., Klingbeil, J., Wrede, K., et al. (2020). Short-term modulation of the lesioned language network. eLife, 9: e54277. doi:10.7554/eLife.54277.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-C36F-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8062-A
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hartwigsen, Gesa1, Author              
Stockert, Anika2, Author              
Charpentier, Louise1, Author
Wawrzyniak, Max2, Author
Klingbeil, Julian2, Author
Wrede, Katrin2, Author
Obrig, Hellmuth3, Author              
Saur , Dorothee2, Author
Affiliations:
1Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
2Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Compensation; Human; Language; Neuroscience; Plasticity; Reorganization; Stroke; Virtual lesion
 Abstract: Language is sustained by large-scale networks in the human brain. Stroke often severely affects function and network dynamics. However, the adaptive potential of the brain to compensate for lesions is poorly understood. A key question is whether upregulation of the right hemisphere is adaptive for language recovery. Targeting the potential for short-term reorganization in the lesioned brain, we applied 'virtual lesions' over left anterior or posterior inferior frontal gyrus (IFG) in post-stroke patients with left temporo-parietal lesions prior to functional neuroimaging. Perturbation of the posterior IFG selectively delayed phonological decisions and decreased phonological activity. The individual response delay was correlated with the upregulation of the lesion homologue, likely reflecting compensation. Moreover, stronger individual tract integrity of the right superior longitudinal fascicle was associated with lesser disruption. Our results provide evidence for functional and structural underpinnings of plasticity in the lesioned language network, and a compensatory role of the right hemisphere.

Details

show
hide
Language(s): eng - English
 Dates: 2019-12-092020-03-022020-03-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.54277
PMID: 32181741
PMC: PMC7077979
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: eLife
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 Sequence Number: e54277 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X