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  Heterochromatin formation in Drosophila requires genome-weide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryongenesis

Walther, M., Schrahn, S., Krauss, V., Lein, S., Kessler, J., Jenuwein, T., et al. (2020). Heterochromatin formation in Drosophila requires genome-weide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryongenesis. Chromosoma: Biology of the Nucleus, 129, 83-98. doi:10.1007/s00412-020-00732-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-C39A-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C39B-0
Genre: Journal Article

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 Creators:
Walther , Matthias1, Author
Schrahn, Sandy1, Author
Krauss, Veiko1, Author
Lein, Sandro1, Author
Kessler, Jaennette1, Author
Jenuwein, Thomas2, Author              
Reuter, Gunter1, Author
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1External Organizations, ou_persistent22              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              

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 Abstract: Su(var) mutations define epigenetic factors controlling heterochromatin formation and gene silencing in Drosophila. Here, we identify SU(VAR)2-1 as a novel chromatin regulator that directs global histone deacetylation during the transition of cleavage chromatin into somatic blastoderm chromatin in early embryogenesis. SU(VAR)2-1 is heterochromatin-associated in blastoderm nuclei but not in later stages of development. In larval polytene chromosomes, SU(VAR)2-1 is a band-specific protein. SU(VAR)2-1 directs global histone deacetylation by recruiting the histone deacetylase RPD3. In Su(var)2-1 mutants H3K9, H3K27, H4K8 and H4K16 acetylation shows elevated levels genome-wide and heterochromatin displays aberrant histone hyperacetylation. Whereas H3K9me2- and HP1a-binding appears unaltered, the heterochromatin-specific H3K9me2S10ph composite mark is impaired in heterochromatic chromocenters of larval salivary polytene chromosomes. SU(VAR)2-1 contains an NRF1/ EWG domain and a C2HC zinc-finger motif. Our study identifies SU(VAR)2-1 as a dosage-dependent, heterochromatininitiating SU(VAR) factor, where the SU(VAR)2-1-mediated control of genome-wide histone deacetylation after cleavage and before mid-blastula transition (pre-MBT) is required to enable heterochromatin formation.

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Language(s): eng - English
 Dates: 2020-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00412-020-00732-x
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Title: Chromosoma : Biology of the Nucleus
  Other : Chromosoma
Source Genre: Journal
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Publ. Info: Wien : Springer-Verlag
Pages: - Volume / Issue: 129 Sequence Number: - Start / End Page: 83 - 98 Identifier: ISSN: 0009-5915
CoNE: https://pure.mpg.de/cone/journals/resource/991042749609288