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  Together we are stronger: fusion protects mitochondria from autophagosomal degradation

Rambold, A., Kostelecky, B., & Lippincott-Schwarz, J. (2011). Together we are stronger: fusion protects mitochondria from autophagosomal degradation. Autophagy, 7, 1568-1569. doi: 10.4161/auto.7.12.17992.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-C45E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C45F-4
Genre: Journal Article

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Rambold et al..pdf (Publisher version), 409KB
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 Creators:
Rambold, Angelika1, Author              
Kostelecky, B.2, Author
Lippincott-Schwarz, J.2, Author
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1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              
2External Organizations, ou_persistent22              

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 Abstract: Starvation induces a protective process of self-cannibalization called autophagy that is thought to mediate nonselective degradation of cytoplasmic material. We recently reported that mitochondria escape autophagosomal degradation through extensive fusion into mitochondrial networks upon certain starvation conditions. The extent of mitochondrial elongation is dependent on the type of nutrient deprivation, with amino acid depletion having a particularly strong effect. Downregulation of the mitochondrial fission protein Drp1 was determined to be important in bringing about starvation-induced mitochondrial fusion. The formation of mitochondrial networks during nutrient depletion selectively blocked their autophagic degradation, presumably allowing cells to sustain efficient ATP production and thereby survive starvation.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.4161/auto.7.12.17992
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Title: Autophagy
Source Genre: Journal
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Publ. Info: Georgetown, TX : Landes Bioscience
Pages: - Volume / Issue: 7 Sequence Number: - Start / End Page: 1568 - 1569 Identifier: ISSN: 1554-8627
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000238500