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  Selective and Reversible Reduction of Odor Sensitivity in the Rat by Concanavalin A

Apfelbach, R., Weiler, E., Asselbergs, W., Polak, E., & Slotnick, B. (1998). Selective and Reversible Reduction of Odor Sensitivity in the Rat by Concanavalin A. Physiology & Behavior, 65(3), 513-516. doi:10.1016/S0031-9384(98)00197-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-C769-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C76A-4
Genre: Journal Article

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Apfelbach, R, Author
Weiler, E1, Author              
Asselbergs, WF, Author
Polak, EH, Author
Slotnick, B, Author
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1External Organizations, ou_persistent22              

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 Abstract: Rats were trained using an olfactometer to detect low concentrations of ethyl acetate (EA) or dimethyl disulphide vapor (DMDS). Concanavalin A (ConA) applied to the olfactory mucosa had no effect on ability of rats to detect low concentrations of EA but produced a marked deficit in detection in DMDS. DMDS detection performance returned to control levels 3 days after the ConA treatment. These results provide the first behavioral evidence for odor-specific inhibition by chemical modification of the olfactory epithelium and support the notion that ConA selectively inactivates one or more types (subclasses) of olfactory receptor proteins.

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 Dates: 1998-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/S0031-9384(98)00197-8
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Title: Physiology & Behavior
Source Genre: Journal
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Publ. Info: New York [etc.] : Elsevier
Pages: - Volume / Issue: 65 (3) Sequence Number: - Start / End Page: 513 - 516 Identifier: ISSN: 0031-9384
CoNE: https://pure.mpg.de/cone/journals/resource/954925433415