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  Increased sensitivity and signal-to-noise ratio in diffusion-weighted MRI using multi-echo acquisitions

Eichner, C., Paquette, M., Mildner, T., Schlumm, T., Pléh, K., Samuni, L., et al. (2020). Increased sensitivity and signal-to-noise ratio in diffusion-weighted MRI using multi-echo acquisitions. bioRxiv. doi:10.1101/2020.03.04.962191.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-C8BC-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-E5E7-3
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 Creators:
Eichner, Cornelius1, Author              
Paquette, Michael1, Author              
Mildner, Toralf2, Author              
Schlumm, Torsten2, Author              
Pléh, Kamilla3, Author
Samuni, Liran3, Author
Crockford, Catherine3, Author
Wittig, Roman M. 3, Author
Jäger, Carsten4, Author              
Möller, Harald E.2, Author              
Friederici, Angela D.1, Author              
Anwander, Alfred1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3External Organizations, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Abstract: Post-mortem diffusion MRI (dMRI) enables high SNR (signal-to-noise ratio) images with high spatial resolution - at the expense of longer scanning times. The typically used segmented image acquisition leads to an incomplete signal decay before continuing the MR coding. Especially in diffusion-weighted MRI, with low signal intensities and lengthy contrast encoding, such inefficiency translates into reduced image quality and longer scanning times. This study introduces Multi Echo (ME) acquisitions to dMRI - a time-efficient approach, which increases SNR and reduces noise bias for dMRI images. The benefit of the introduced ME dMRI method were validated using Monte Carlo simulations and applied on a post mortem wild chimpanzee brain. The proposed strategy comes at a small price in scanning time (here 30% additional) and leads to increased SNR (here 1.9x) and a general reduction of the noise bias.

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Language(s): eng - English
 Dates: 2020-03-04
 Publication Status: Published online
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 Rev. Type: No review
 Identifiers: DOI: 10.1101/2020.03.04.962191
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Title: bioRxiv
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