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  Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording

Pais-Roldán, P., Takahashi, K., Sobczak, F., Chen, Y., Zhao, X., Zeng, H., et al. (2020). Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording. Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6875-6882. doi:10.1073/pnas.1909937117.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-D4BE-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-F72F-1
Genre: Journal Article

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 Creators:
Pais-Roldán, P1, 2, Author              
Takahashi, K1, 2, Author              
Sobczak, F1, 2, Author              
Chen, Y1, 2, Author              
Zhao, X1, 2, Author              
Zeng, H1, 2, Author              
Jiang, Y1, 2, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Pupillometry, a noninvasive measure of arousal, complements human functional MRI (fMRI) to detect periods of variable cognitive processing and identify networks that relate to particular attentional states. Even under anesthesia, pupil dynamics correlate with brain-state fluctuations, and extended dilations mark the transition to more arousable states. However, cross-scale neuronal activation patterns are seldom linked to brain state-dependent pupil dynamics. Here, we complemented resting-state fMRI in rats with cortical calcium recording (GCaMP-mediated) and pupillometry to tackle the linkage between brain-state changes and neural dynamics across different scales. This multimodal platform allowed us to identify a global brain network that covaried with pupil size, which served to generate an index indicative of the brain-state fluctuation during anesthesia. Besides, a specific correlation pattern was detected in the brainstem, at a location consistent with noradrenergic cell group 5 (A5), which appeared to be dependent on the coupling between different frequencies of cortical activity, possibly further indicating particular brain-state dynamics. The multimodal fMRI combining concurrent calcium recordings and pupillometry enables tracking brain state-dependent pupil dynamics and identifying unique cross-scale neuronal dynamic patterns under anesthesia.

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 Dates: 2020-032020-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.1909937117
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 117 (12) Sequence Number: - Start / End Page: 6875 - 6882 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230