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  Evidence for an enhanced procoagulant state in remitted major depression

von Kaenel, R., Merz, F., Pfister, H., Brueckl, T., Zimmermann, P., Uhr, M., et al. (2019). Evidence for an enhanced procoagulant state in remitted major depression. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. doi:10.1080/15622975.2019.1696475.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-F73B-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-F73C-2
Genre: Journal Article

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von Kaenel, Roland, Author
Merz, Franziska1, Author              
Pfister, Hildegard1, 2, Author              
Brueckl, Tanja1, 2, 3, 4, 5, Author              
Zimmermann, Petra1, 2, 3, 4, Author              
Uhr, Manfred4, 5, 6, 7, Author              
Holsboer, Florian1, 4, 8, 9, Author              
Hoehne, Nina1, 2, 3, Author              
Ising, Marcus1, 2, 3, 4, Author              
Affiliations:
1Dept. Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035296              
2AG Ising, Marcus, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607149              
3RG Marcus Ising, Molecular Psychology, Dept. Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040298              
4Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035296              
5Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
6Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              
7AG Uhr, Manfred, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607163              
8Emeritiertes wissenschaftliches Mitglied, Max Planck Institute of Psychiatry, Max Planck Society, ou_2074301              
9Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607139              

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 Abstract: Objectives: Hypercoagulability is one mechanism to explain the increased risk of incident atherothrombotic disease in patients with major depressive disorder (MDD). We examined whether patients with remitted MDD show an enhanced procoagulant state. Methods: 63 individuals (median age 35 years, 59% women), 40 with a DSM-IV diagnosis of remitted MDD, made by a clinical interview, and 23 healthy controls provided blood samples for the measurement of fibrinogen, D-dimer, von Willebrand factor, and plasminogen activator inhibitor-1. Standardised z-scores of plasma levels of these haemostatic factors were added to form a procoagulant index (PCI) as the primary outcome variable. Self-ratings of residual depressive symptoms and trait anxiety were also obtained. Results: Compared with controls, remitted MDD patients had higher PCI (p = 0.013, Cohen's d = 0.69) and fibrinogen (p = 0.001, d = 0.91), controlling for age, sex, body mass index, smoking and C-reactive protein. There were no significant associations of the PCI and individual haemostatic molecules with age of MDD onset, time since the last MDD episode, the number of previous MDD episodes and residual depressive symptoms. Additional adjustment for anxiety symptoms did not change these results. Conclusions: Remitted MDD is associated with an enhanced procoagulant state. Hypercoagulability seems more a trait than a state characteristic of depression.

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 Dates: 2019-12-09
 Publication Status: Published online
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Title: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1562-2975