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  Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients

Papiol, S., Keeser, D., Hasan, A., Schneider-Axmann, T., Raabe, F., Degenhardt, F., et al. (2019). Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients. Translational Psychiatry, 9: 284. doi:10.1038/s41398-019-0618-z.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-FAAA-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-FAAB-1
Genre: Journal Article

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 Creators:
Papiol, Sergi, Author              
Keeser, Daniel, Author
Hasan, Alkomiet, Author
Schneider-Axmann, Thomas, Author
Raabe, Florian1, Author              
Degenhardt, Franziska, Author
Rossner, Moritz J., Author              
Bickeboeller, Heike, Author
Cantuti-Castelvetri, Ludovico2, Author              
Simons, Mikael, Author              
Wobrock, Thomas, Author
Schmitt, Andrea3, Author              
Malchow, Berend, Author
Falkai, Peter, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_1607137              
2Cellular neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173650              
3Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              

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 Abstract: Hippocampal volume decrease is a structural hallmark of schizophrenia (SCZ), and convergent evidence from postmortem and imaging studies suggests that it may be explained by changes in the cytoarchitecture of the cornu ammonis 4 (CA4) and dentate gyrus (DG) subfields. Increasing evidence indicates that aerobic exercise increases hippocampal volume in CA subfields and improves cognition in SCZ patients. Previous studies showed that the effects of exercise on the hippocampus might be connected to the polygenic burden of SCZ risk variants. However, little is known about cell type-specific genetic contributions to these structural changes. In this secondary analysis, we evaluated the modulatory role of cell type-specific SCZ polygenic risk scores (PRS) on volume changes in the CA1, CA2/3, and CA4/DG subfields over time. We studied 20 multi-episode SCZ patients and 23 healthy controls who performed aerobic exercise, and 21 multi-episode SCZ patients allocated to a control intervention (table soccer) for 3 months. Magnetic resonance imaging-based assessments were performed with FreeSurfer at baseline and after 3 months. The analyses showed that the polygenic burden associated with oligodendrocyte precursor cells (OPC) and radial glia (RG) significantly influenced the volume changes between baseline and 3 months in the CA4/DG subfield in SCZ patients performing aerobic exercise. A higher OPC- or RG-associated genetic risk burden was associated with a less pronounced volume increase or even a decrease in CA4/DG during the exercise intervention. We hypothesize that SCZ cell type-specific polygenic risk modulates the aerobic exercise-induced neuroplastic processes in the hippocampus.

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Language(s): eng - English
 Dates: 2019-11-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000497957700004
DOI: 10.1038/s41398-019-0618-z
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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
 Creator(s):
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 9 Sequence Number: 284 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188