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  Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma. Frontiers in Psychiatry, 10: 808. doi:10.3389/fpsyt.2019.00808.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-FAAD-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-FAAE-E
Genre: Journal Article

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 Creators:
Jiang, Shui, Author
Postovit, Lynne, Author
Cattaneo, Annamaria, Author
Binder, Elisabeth B.1, 2, Author              
Aitchison, Katherine J., Author
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Adverse childhood experiences (ACEs) may be referred to by other terms (e.g., early life adversity or stress and childhood trauma) and have a lifelong impact on mental and physical health. For example, childhood trauma has been associated with posttraumatic stress disorder (PTSD), anxiety, depression, bipolar disorder, diabetes, and cardiovascular disease. The heritability of ACE-related phenotypes such as PTSD, depression, and resilience is low to moderate, and, moreover, is very variable for a given phenotype, which implies that gene by environment interactions (such as through epigenetic modifications) may be involved in the onset of these phenotypes. Currently, there is increasing interest in the investigation of epigenetic contributions to ACE-induced differential health outcomes. Although there are a number of studies in this field, there are still research gaps. In this review, the basic concepts of epigenetic modifications (such as methylation) and the function of the hypothalamic-pituitary-adrenal (HPA) axis in the stress response are outlined. Examples of specific genes undergoing methylation in association with ACE-induced differential health outcomes are provided. Limitations in this field, e.g., uncertain clinical diagnosis, conceptual inconsistencies, and technical drawbacks, are reviewed, with suggestions for advances using new technologies and novel research directions. We thereby provide a platform on which the field of ACE-induced phenotypes in mental health may build.

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Language(s): eng - English
 Dates: 2019-11-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000499478900001
DOI: 10.3389/fpsyt.2019.00808
 Degree: -

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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 808 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640