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  Muscle-selective RUNX3 dependence of sensorimotor circuit development

Wang, Y., Wu, H., Zelenin, P., Fontanet, P., Wanderoy, S., Petitpre, C., et al. (2019). Muscle-selective RUNX3 dependence of sensorimotor circuit development. Development, 146(20): dev181750. doi:10.1242/dev.181750.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-FBD1-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-FBD2-3
Genre: Journal Article

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 Creators:
Wang, Yiqiao, Author
Wu, Haohao, Author
Zelenin, Pavel, Author
Fontanet, Paula, Author
Wanderoy, Simone, Author
Petitpre, Charles, Author
Comai, Glenda, Author
Bellardita, Carmelo, Author
Xue-Franzen, Yongtao, Author
Huettl, Rosa-Eva1, Author              
Huber, Andrea B., Author
Tajbakhsh, Shahragim, Author
Kiehn, Ole, Author
Ernfors, Patrik, Author
Deliagina, Tatiana G., Author
Lallemend, Francois, Author
Hadjab, Saida, Author
Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              

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 Abstract: The control of all our motor outputs requires constant monitoring by proprioceptive sensory neurons (PSNs) that convey continuous muscle sensory inputs to the spinal motor network. Yet the molecular programs that control the establishment of this sensorimotor circuit remain largely unknown. The transcription factor RUNX3 is essential for the early steps of PSNs differentiation, making it difficult to study its role during later aspects of PSNs specification. Here, we conditionally inactivate Runx3 in PSNs after peripheral innervation and identify that RUNX3 is necessary for maintenance of cell identity of only a subgroup of PSNs, without discernable cell death. RUNX3 also controls the sensorimotor connection between PSNs and motor neurons at limb level, with muscle-by-muscle variable sensitivities to the loss of Runx3 that correlate with levels of RUNX3 in PSNs. Finally, we find that muscles and neurotrophin 3 signaling are necessary for maintenance of RUNX3 expression in PSNs. Hence, a transcriptional regulator that is crucial for specifying a generic PSN type identity after neurogenesis is later regulated by target muscle-derived signals to contribute to the specialized aspects of the sensorimotor connection selectivity.

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Language(s): eng - English
 Dates: 2019-10-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000493947200036
DOI: 10.1242/dev.181750
 Degree: -

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Title: Development
  Other : Development
Source Genre: Journal
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Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 146 (20) Sequence Number: dev181750 Start / End Page: - Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241