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  Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium

Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O., Lahti, J., Page, C. M., et al. (2019). Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium. Hypertension, 74(2), 375-383. doi:10.1161/HYPERTENSIONAHA.119.12634.

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Kazmi, Nabila, Author
Sharp, Gemma C., Author
Reese, Sarah E., Author
Vehmeijer, Florianne O., Author
Lahti, Jari, Author
Page, Christian M., Author
Zhang, Weiming, Author
Rifas-Shiman, Sheryl L., Author
Rezwan, Faisal I., Author
Simpkin, Andrew J., Author
Burrows, Kimberley, Author
Richardson, Tom G., Author
Ferreira, Diana L. Santos, Author
Fraser, Abigail, Author
Harmon, Quaker E., Author
Zhao, Shanshan, Author
Jaddoe, Vincent W. V., Author
Czamara, Darina1, Author           
Binder, Elisabeth B.1, Author           
Magnus, Maria C., Author
Haberg, Siri E., AuthorNystad, Wenche, AuthorNohr, Ellen A., AuthorStarling, Anne P., AuthorKechris, Katerina J., AuthorYang, Ivana V., AuthorDeMeo, Dawn L., AuthorLitonjua, Augusto A., AuthorBaccarelli, Andrea, AuthorOken, Emily, AuthorHolloway, John W., AuthorKarmaus, Wilfried, AuthorArshad, Syed H., AuthorDabelea, Dana, AuthorSorensen, Thorkild I. A., AuthorLaivuori, Hannele, AuthorRaikkonen, Katri, AuthorFelix, Janine F., AuthorLondon, Stephanie J., AuthorHivert, Marie-France, AuthorGaunt, Tom R., AuthorLawlor, Debbie A., AuthorRelton, Caroline L., Author more..
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              


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 Abstract: Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R-2=0.26). In longitudinal analyses conducted in 1 study (n=108 HDP cases; 550 controls), there were similar changes in DNA methylation in offspring of those with and without HDP up to adolescence. Pathway analysis suggested that genes located at/near HDP-associated sites may be involved in developmental, embryogenesis, or neurological pathways. HDP is associated with offspring DNA methylation with potential relevance to development.


Language(s): eng - English
 Dates: 2019-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Source 1

Title: Hypertension
Source Genre: Journal
Publ. Info: Philadelphia, PA : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 74 (2) Sequence Number: - Start / End Page: 375 - 383 Identifier: ISSN: 0194-911X
CoNE: https://pure.mpg.de/cone/journals/resource/954925490865