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  Polymer‐based porous microcapsules as bacterial traps

Luo, R., Pashapour, S., Staufer, O., Platzman, I., & Spatz, J. P. (2020). Polymer‐based porous microcapsules as bacterial traps. Advanced Functional Materials, e-pup: 1908855, pp. 1-10. doi:10.1002/adfm.201908855.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-DA19-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DA1A-9
Genre: Journal Article

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 Creators:
Luo, Rongcong1, Author              
Pashapour, Sadaf1, Author              
Staufer, Oskar2, 3, Author              
Platzman, Ilia2, 3, Author              
Spatz, Joachim P.2, 3, Author              
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
3Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Exposure to live bacteria and accumulation of dead bacteria during bactericidal processes can cause bacterial infectious diseases, implant failure, and antibacterial surface deterioration. Microcapsules with asymmetrically distributed, funnel‐shaped pores, which are capable of capturing, retaining, and killing bacteria are developed, offering a solution to bacterial contamination in liquids. It is found that bacterial isolation inside microcapsules is mainly driven by the bacteria's own motility and the microcapsules' geometry. After entry into the microcapsule cavity, the bacteria are stably retained inside. The microcapsules shield surrounding cells from exposure to bacterial toxins, as demonstrated by the coculture of rat embryonic fibroblast cells with microcapsules loaded with live Escherichia coli. The microcapsules can be enhanced with a bactericidal coating covering only the interior cavity. This confines the bacteria‐killing process, thereby further increasing biocompatibility. The microcapsules may offer a viable bacteria combatant approach as a potentially advantageous method to eradicate bacterial contamination.

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Language(s): eng - English
 Dates: 2020-01-162019-10-252020
 Publication Status: Published in print
 Pages: 10
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/adfm.201908855
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Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: e-pup Sequence Number: 1908855 Start / End Page: 1 - 10 Identifier: ISSN: 1616-301X
CoNE: https://pure.mpg.de/cone/journals/resource/954925596563