English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia: A Pilot Study

Hammans, C., Neugebauer, K., Kumar, V., Mevissen, L., Sternkopf, M., Novakovic, A., et al. (2020). BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia: A Pilot Study. Frontiers in Psychiatry, 11: 31, pp. 1-10. doi:10.3389/fpsyt.2020.00031.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-DB65-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DB66-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Hammans, C, Author
Neugebauer, K, Author
Kumar, V1, 2, Author              
Mevissen, L, Author
Sternkopf, MA, Author
Novakovic, A, Author
Wensing, T, Author
Habel, U, Author
Abel, T, Author
Nickl-Jockschat, T, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Brain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of schizophrenia. As BDNF regulates axonal and dendritic growth, altered BDNF levels in schizophrenia patients might underlie changes in structural connectivity that have been identified by magnetic resonance imaging (MRI). We investigated a possible correlation between BDNF serum levels, fiber tract architecture, and regional grey matter volumes in 19 schizophrenia patients and a gender- and age-matched control group. Two patients had to be excluded due to abnormalities in their MRI scans. Serum samples were obtained to determine BDNF levels, and T1- as well as diffusion-weighted sequences were acquired. We, then, investigated correlations between BDNF serum levels with neuroimaging parameters, using Voxel-based Morphometry (VBM) and Tract-based Spatial Statistics (TBSS). We found a significant negative correlation between BDNF serum levels and FA values in the right inferior fronto-occipital fasciculus and the right superior longitudinal fasciculus. These regions also showed a decrease in AD values in schizophrenia patients. Grey matter volumes were reduced in patients but there was no correlation between regional grey matter volumes and BDNF. The right superior longitudinal fasciculus has been repeatedly identified to exhibit microstructural changes in schizophrenia patients. Our findings of a negative correlation between BDNF and FA values in patients might indicate that BDNF is upregulated to compensate decreased structural connectivity as it induces neural plasticity and shows increased levels in damaged tissue. These findings of our pilot study are encouraging leads for future research in larger samples.

Details

show
hide
Language(s):
 Dates: 2020-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fpsyt.2020.00031
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 31 Start / End Page: 1 - 10 Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640