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  Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging

Ovsepian, S., Jiang, Y., Sardella, T., Malekzadeh-Najafabadi, J., Burton, N., Yu, X., et al. (2020). Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging. Photoacoustics, 17: 100153, pp. 1-4. doi:10.1016/j.pacs.2019.100153.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-DB6F-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DB70-6
Genre: Journal Article

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 Creators:
Ovsepian, SV, Author
Jiang, Y, Author
Sardella, TCP, Author
Malekzadeh-Najafabadi , J, Author
Burton, NC, Author
Yu, X1, 2, Author              
Ntziachristos , V, Author
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.

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 Dates: 2019-122020-03
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.pacs.2019.100153
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Title: Photoacoustics
Source Genre: Journal
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Pages: - Volume / Issue: 17 Sequence Number: 100153 Start / End Page: 1 - 4 Identifier: ISSN: 2213-5979