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  Many lives of KATs - detector, integrator and modulator of cellular environment

Sheikh, B., & Akhtar, A. (2019). Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics, 20, 7-23. doi:10.1038/s41576-018-0072-4.

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Sheikh, Bilal1, Author
Akhtar, Asifa1, Author              
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1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: Research over the past three decades has firmly established lysine acetyltransferases (KATs) as central players in regulating transcription. Recent advances in genomic sequencing, metabolomics, animal models and mass spectrometry technologies have uncovered unexpected new roles for KATs at the nexus between the environment and transcriptional regulation. Thousands of reversible acetylation sites have been mapped in the proteome that respond dynamically to the cellular milieu and maintain major processes such as metabolism, autophagy and stress response. Concurrently, researchers are continuously uncovering how deregulation of KAT activity drives disease, including cancer and developmental syndromes characterized by severe intellectual disability. These novel findings are reshaping our view of KATs away from mere modulators of chromatin to detectors of the cellular environment and integrators of diverse signalling pathways with the ability to modify cellular phenotype.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41576-018-0072-4
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Title: Nature Reviews Genetics
Source Genre: Journal
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Publ. Info: London, UK : Nature Pub. Group
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 7 - 23 Identifier: ISSN: 1471-0056
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000939