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  The influence of metal ion complexation on 31P-NMR parameters of phosphorothioates of guanosine nucleotides

Rösch, P., Goody, R. S., & Isakov, M. (1984). The influence of metal ion complexation on 31P-NMR parameters of phosphorothioates of guanosine nucleotides. Phosphorus Sulfur and Silicon and the Related Elements, 9-16. doi:10.1080/03086648408073121.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-DFBB-E Version Permalink: https://hdl.handle.net/21.11116/0000-0005-DFBC-D
Genre: Journal Article

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PhosSulf_21_1984_9.pdf (Any fulltext), 586KB
 
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 Creators:
Rösch, Paul1, Author           
Goody, Roger S.2, Author           
Isakov, Maria3, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
2Abt. III: Physikalische Biochemie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753289              
3Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: An extension of methods already used for the preparation of adenosine phosphorothioates was used to prepare guanosine phosphorothioates in quantities sufficient for extensive 31P-NMR studies. Guanosine phosphorothioates were used to exemplify the influence of Cd2+ and Mg2+ complexation on 31P-NMR parameters as pK-values, chemical shifts, and P[sbnd]O[sbnd]P coupling constants. pKa values decrease in general in the order pK(α-S) a > pK(β-S) a > pK(γ-S) a; the magnitude of the pKa decrease on metal complexation is also in this order. The chemical shifts for the P[sbnd]S resonances are changed downfield on Mg2+ complexation and upfield on Cd2+ complexation. P[sbnd]O[sbnd]P coupling constants are increased by about 7 Hz on sulfur substitution at one of the contributing phosphorus atoms; this difference is at least partially ineffective in the Cd2+ complexes.

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Language(s): eng - English
 Dates: 1984-04-131984-05-242006-12-131984
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/03086648408073121
 Degree: -

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Title: Phosphorus Sulfur and Silicon and the Related Elements
  Other : Phosphorus Sulfur Silicon Relat. Elem.
Source Genre: Journal
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Publ. Info: New York : Gordon and Breach.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 9 - 16 Identifier: ISSN: 0308-664X
CoNE: https://pure.mpg.de/cone/journals/resource/954925589382