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  The MSL complex: X chromsome and beyond

Laverty, C., Lucci, J., & Akhtar, A. (2010). The MSL complex: X chromsome and beyond. Current Opinion in Genetics & Development, 20, 171-178. doi:10.1016/j.gde.2010.01.007.

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 Creators:
Laverty, C.1, Author
Lucci, J.1, Author
Akhtar, Asifa2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: X chromosomal regulation is a process that presents systematic problems of chromosome recognition and coordinated gene regulation. In Drosophila males, the ribonucleoprotein Male-Specific Lethal (MSL) complex plays an important role in hyperactivation of the X-linked genes to equalize gene dosage differences between the sexes. It appears that X chromosome recognition by the MSL complex may be mediated through a combination of sequence-specificity and transcriptional activities. The resulting transcriptional up-regulation also seems to involve several mechanisms, encompassing both gene-specific and chromosome-wide approaches. Interestingly the histone H4 lysine 16 specific MOF histone acetyl transferase, a key MSL member that hyper-acetylates the male X chromosome, is also involved in gene regulation beyond dosage compensation. A comparison of Drosophila and mammalian systems reveals intriguing parallels in MOF behavior, and highlights the multidisciplinary nature of this enzyme.

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Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.gde.2010.01.007
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Title: Current Opinion in Genetics & Development
  Other : Curr. Opin. Genet. Dev.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Elsevier Current Trends
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 171 - 178 Identifier: ISSN: 0959-437X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578065