English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Critical steps of Plasmodium falciparum ookinete maturation

Siciliano, G., Costa, G., Suárez-Cortés, P., Valleriani, A., Alano, P., & Levashina, E. A. (2020). Critical steps of Plasmodium falciparum ookinete maturation. Frontiers in Microbiology, 11: 269. doi:10.3389/fmicb.2020.00269.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-E519-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-E51A-C
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Supplementary material), 3MB
Name:
Article.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Siciliano, Giulia, Author
Costa, Giulia, Author
Suárez-Cortés, Pablo, Author
Valleriani, Angelo1, Author              
Alano, Pietro, Author
Levashina, Elena A., Author
Affiliations:
1Angelo Valleriani, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863324              

Content

show
hide
Free keywords: malaria parasite transmission, Plasmodium falciparum, Anopheles coluzzii, ookinete maturation, time course of zygote development, developmental bottleneck
 Abstract: The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists about the cell biology and regulation of this process. Technical impediments in the establishment of in vitro conditions for ookinete maturation in Plasmodium falciparum and other human malaria parasites further constrain a detailed characterization of ookinete maturation. Here, using fluorescence microscopy and immunolabeling, we compared P. falciparum ookinete maturation in Anopheles coluzzii mosquitoes in vivo and in cell culture in vitro. Our results identified two critical steps in ookinete maturation that are regulated by distinct mosquito factors, thereby highlighting the role of the mosquito environment in the transmission efficiency of malaria parasites.

Details

show
hide
Language(s): eng - English
 Dates: 2020-03-172020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fmicb.2020.00269
BibTex Citekey: 10.3389/fmicb.2020.00269
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Microbiology
  Abbreviation : Front. Microbiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 11 Sequence Number: 269 Start / End Page: - Identifier: ISSN: 1664-302X