English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture

Hu, J., Wu, W., Qin, Y., Liu, C., Wei, P., Hu, J., et al. (2020). Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture. Advanced Functional Materials, 30(19): 1910084. doi:10.1002/adfm.201910084.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-EB33-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-7887-B
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 11MB
 
File Permalink:
-
Name:
Article.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Hu, Jun, Author
Wu, Wenrui, Author
Qin, Yufei, Author
Liu, Chao, Author
Wei, Peng, Author
Hu, Jing, Author
Seeberger, Peter H.1, Author              
Yin, Jian, Author
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

Content

show
hide
Free keywords: chemotherapy, glyco-metal-organic frameworks, hepatocellular carcinoma, interventional photodynamic therapy
 Abstract: Abstract Hepatocellular carcinoma (HCC) causes high morbidity and mortality due to a lack of adequate treatments. Cancer treatments have benefited from nanotechnology approaches that integrate multimodal synergistic therapies. A synergistic, minimally invasive strategy of interventional photodynamic therapy (IPDT) and chemotherapy for HCC treatment through percutaneous transperitoneal puncture is disclosed that is based on photosensitive porphyrinic galactose-modified metal-organic frameworks (PCN-224) first used as hepatic targeting and encapsulated with anticancer drug doxorubicin (DOX@Gal-PCN-224). Real-time imaging reveals the effective accumulation of the integrated nanosystem in the HCC cells and tumor tissues due to hepatic targeting. Evaluation of the anti-tumor efficiency of this nanosystem on orthotopic transplantation tumors with the aid of minimally invasive intervention shows a tumor inhibition rate of 98%. The synergistic effects induce high-level cell apoptosis and tissue necrosis in vitro and in vivo. This bimodal IPDT/chemotherapy strategy holds great potential in the clinical treatment for HCC.

Details

show
hide
Language(s): eng - English
 Dates: 2020-03-122020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/adfm.201910084
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: 30 (19) Sequence Number: 1910084 Start / End Page: - Identifier: ISSN: 1616-301X