English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Global and regional development of the human cerebral cortex: Molecular crchitecture and occupational aptitudes

Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., et al. (2020). Global and regional development of the human cerebral cortex: Molecular crchitecture and occupational aptitudes. Cerebral Cortex, 30(7), 4121-4139. doi:10.1093/cercor/bhaa035.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-812E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-812F-4
Genre: Journal Article

Files

show Files
hide Files
:
bhaa035_20-03-2020.pdf (Publisher version), 2MB
Name:
bhaa035_20-03-2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Shin, Jean, Author
Ma, Shaojie, Author
Hofer, Edith, Author
Patel, Yash, Author
Vosberg, Daniel E., Author
Tilley, Steven, Author
Roshchupkin, Gennady V , Author
Sousa, André M M , Author
Jian, Xueqiu, Author
Gottesman, Rebecca, Author
Mosley, Thomas H., Author
Fornage, Myriam, Author
Saba, Yasaman, Author
Pirpamer, Lukas, Author
Schmidt, Reinhold, Author
Schmidt , Helena, Author
Carrion-Castillo, Amaia, Author
Crivello, Fabrice, Author
Mazoyer, Bernard, Author
Bis, Joshua C, Author
Li, Shuo, AuthorYang, Qiong, AuthorLuciano, Michelle, AuthorKarama, Sherif, AuthorLewis, Lindsay, AuthorBastin, Mark E, AuthorHarris, Mathew A, AuthorWardlaw, Joanna M, AuthorDeary, Ian E, AuthorScholz , Markus, AuthorLoeffler, Markus, AuthorWitte, A. Veronica1, Author              Beyer, Frauke1, Author              Villringer, Arno1, Author              Armstrong, Nicola F, AuthorMather, Karen A, AuthorAmes, David, AuthorJiang, Jiyang, AuthorKwok, John B, AuthorSchofield, Peter R, AuthorThalamuthu, Anbupalam , AuthorTrollor, Julian N, AuthorWright, Margaret J, AuthorBrodaty, Henry, AuthorWen, Wei, AuthorSachdev, Perminder S, AuthorTerzikhan, Natalie , AuthorEvans, Tavia E, AuthorAdams, Hieab H H H , AuthorIkram, M Arfan, AuthorFrenzel, Stefan, AuthorAuwera-Palitschka, Sandra van der, AuthorWittfeld, Katharina, AuthorBülow, Robin, AuthorGrabe, Hans Jörgen, AuthorTzourio, Christophe, AuthorMishra, Aniket, AuthorMaingault, Sophie , AuthorDebette, Stephanie , AuthorGillespie, Nathan A, AuthorFranz, Carol E, AuthorKremen, William S, AuthorDing, Linda, AuthorJahanshad, Neda, AuthorSestan, Nenad, AuthorPausova, Zdenka , AuthorSeshadri, Sudha , AuthorPaus, Tomas, Authorthe ENIGMA Consortium, Author              for the neuroCHARGE Working Group, Author               more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Brain development; Cortical surface area; Cortical thickness; Genome-wide association study; Occupational aptitude
 Abstract: We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.

Details

show
hide
Language(s): eng - English
 Dates: 2020-03-202020-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1093/cercor/bhaa035
PMID: 32198502
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 30 (7) Sequence Number: - Start / End Page: 4121 - 4139 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440