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  Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind

Tholen, M., Trautwein, F.-M., Böckler, A., Singer, T., & Kanske, P. (2020). Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind. Human Brain Mapping. doi:10.1002/hbm.24966.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-F273-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-62BF-5
Genre: Journal Article

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 Creators:
Tholen, Matthias1, Author
Trautwein, Fynn-Mathis2, Author              
Böckler, Anne3, Author              
Singer, Tania4, Author              
Kanske, Philipp5, 6, Author              
Affiliations:
1Department of Psychology, Centre for Cognitive Neuroscience, University of Salzburg, Austria, ou_persistent22              
2Edmond Safra Brain Research Center, Faculty of Education, University of Haifa, Israel, ou_persistent22              
3Department of Psychology, Gottfried Wilhelm Leibniz University, Hannover, Germany, ou_persistent22              
4Social Neuroscience Lab, Berlin, Germany, ou_persistent22              
5Chair for Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
6Research Group Social Stress and Family Health, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025667              

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Free keywords: Affect sharing; Anterior insula; Mentalizing; Social cognition; Temporoparietal junction
 Abstract: In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM) that measures the neural correlates of empathy and Theory of Mind (ToM). The task includes a large stimulus set (240 emotional vs. neutral videos to probe empathic responding and 240 ToM or factual reasoning questions to probe ToM), which we tested in two large participant samples (N = 178, N = 130). Both, the empathy‐related network comprising anterior insula, anterior cingulate/dorsomedial prefrontal cortex, inferior frontal gyrus, and dorsal temporoparietal junction/supramarginal gyrus (TPJ) and the ToM related network including ventral TPJ, superior temporal gyrus, temporal poles, and anterior and posterior midline regions, were observed across participants and items. Regression analyses confirmed that these activations are predicted by the empathy or ToM condition of the stimuli, but not by low‐level features such as video length, number of words, syllables or syntactic complexity. The item analysis also allowed for the selection of the most effective items to create optimized stimulus sets that provide the most stable and reproducible results. Finally, reproducibility was shown in the replication of all analyses in the second participant sample. The data demonstrate (a) the generalizability of empathy and ToM related neural activity and (b) the reproducibility of the EmpaToM task and its applicability in intervention and clinical imaging studies.

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Language(s): eng - English
 Dates: 2020-02-052019-07-042020-02-112020-03-02
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/hbm.24966
PMID: 32115820
Other: Epub ahead of print
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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686