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  Quantitative mechanisms of DNA damage sensing and signaling

Bantele, S. C. S., & Pfander, B. (2020). Quantitative mechanisms of DNA damage sensing and signaling. CURRENT GENETICS, 66(1), 59-62. doi:10.1007/s00294-019-01007-4.

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Bantele-Pfander2020_Article_QuantitativeMechanismsOfDNADam.pdf (Any fulltext), 699KB
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Bantele-Pfander2020_Article_QuantitativeMechanismsOfDNADam.pdf
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 Creators:
Bantele, Susanne C. S.1, Author              
Pfander, Boris1, Author              
Affiliations:
1Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565165              

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Free keywords: SINGLE-STRANDED-DNA; REPLICATION PROTEIN-A; CHECKPOINT KINASE; BREAK REPAIR; CHROMATIN; ACTIVATION; PHOSPHORYLATION; RECOMBINATION; DYNAMICS; YEASTDNA damage checkpoint; Signal transduction; Double strand break; DNA end resection; Cell cycle; Post-translational modification; Genome stability;
 Abstract: DNA damage occurs abundantly during normal cellular proliferation. This necessitates that cellular DNA damage response and checkpoint pathways monitor the cellular DNA damage load and that DNA damage signaling is quantitative. Yet, how DNA lesions are counted and converted into a quantitative response remains poorly understood. We have recently obtained insights into this question investigating DNA damage signaling elicited by single-stranded DNA (ssDNA). Intriguingly, our findings suggest that local and global DNA damage signaling react differentially to increasing amounts of DNA damage. In this mini-review, we will discuss these findings and put them into perspective of current knowledge on the DNA damage response.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: CURRENT GENETICS
Source Genre: Journal
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Publ. Info: ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES : SPRINGER
Pages: - Volume / Issue: 66 (1) Sequence Number: - Start / End Page: 59 - 62 Identifier: ISSN: 0172-8083