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  Dissociable neural effects of temporal expectations due to passage of time and contextual probability

Todorovic, A., & Auksztulewicz, R. (2021). Dissociable neural effects of temporal expectations due to passage of time and contextual probability. Hearing Research, 399: 107871. doi:10.1016/j.heares.2019.107871.

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 Creators:
Todorovic, Ana1, 2, 3, Author
Auksztulewicz, Ryszard1, 4, 5, Author           
Affiliations:
1Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK, ou_persistent22              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Experimental Psychology, University of Oxford, Oxford, UK, ou_persistent22              
4Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
5Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, ou_persistent22              

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Free keywords: Temporal prediction, Predictive coding, Hazard rate, Auditory processing, Magnetoencephalography, Dynamic causal modelling
 Abstract: The human brain is equipped with complex mechanisms to track the changing probability of events in time. While the passage of time itself usually leads to a mounting expectation, context can provide additional information about when events are likely to happen. In this study we dissociate these two sources of temporal expectation in terms of their neural correlates and underlying brain connectivity patterns. We analysed magnetoencephalographic (MEG) data acquired from N = 24 healthy participants listening to auditory stimuli. These stimuli could be presented at different temporal intervals but occurred most often at intermediate intervals, forming a contextual probability distribution. Evoked MEG response amplitude was sensitive to both passage of time (time elapsed since the cue) and contextual probability, albeit at different latencies: the effects of passage of time were observed earlier than the effects of context. The underlying sources of MEG activity were also different across the two types of temporal prediction: the effects of passage of time were localised to early auditory regions and superior temporal gyri, while context was additionally linked to activity in inferior parietal cortices. Finally, these differences were modelled using biophysical (dynamic causal) modelling: passage of time was explained in terms of widespread gain modulation and decreased prediction error signalling at lower levels of the hierarchy, while contextual expectation led to more localised gain modulation and decreased prediction error signalling at higher levels of the hierarchy. These results present a comprehensive account of how independent sources of temporal prediction may be differentially expressed in cortical circuits.

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Language(s): eng - English
 Dates: 2019-11-222019-09-112019-12-092019-12-192021-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.heares.2019.107871
 Degree: -

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Title: Hearing Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 399 Sequence Number: 107871 Start / End Page: - Identifier: ISSN: 0378-5955
CoNE: https://pure.mpg.de/cone/journals/resource/954925527845