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Free keywords:
Extracellular matrix ; cell adhesion ; integrins ; growth factors ; surface micropatterning ; nanopatterning
Abstract:
The extracellular environment (ECM) comprises multiple physical and chemical cues that are integrated into adhesion signaling pathways and modulate cell responses fundamental for tissue regeneration. In this chapter, we will outline the importance of ECM molecule and ECM-synthetic ligand presentations in biomaterial design. In particular, we will discuss the use of different chemical linkers that allow the control over surface immobilization, orientation, and release of such molecules and ligands. We will next present different strategies for the delivery of adhesive ligands and growth factors on material surfaces, with the aim of enhancing cell adhesion strength and signaling. A final discussion will be centered on challenges in the design of surfaces to precisely guide cell responses during tissue growth and wound healing.
