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  Advances in the evolutionary understanding of MHC polymorphism

Radwan, J., Babik, W., Kaufman, J., Lenz, T. L., & Winternitz, J. (2020). Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics, 36(4), 298-311. doi:10.1016/j.tig.2020.01.008.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-013E-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-0142-E
Genre: Journal Article

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PIIS0168952520300214.pdf (Publisher version), 2MB
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 Creators:
Radwan, Jacek, Author
Babik, Wiesław, Author
Kaufman, Jim, Author
Lenz, Tobias L.1, Author              
Winternitz, Jamie, Author
Affiliations:
1Emmy Noether Research Group Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2616693              

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 Abstract: Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies. Recent studies provide evidence that these features may arise due to pathogens evolving ways to evade immune response guided by the locally common MHC alleles. However, complexities of selection on MHC genes are simultaneously being revealed that need to be incorporated into existing theory. These include pathogen-driven selection for antigen-binding breadth and expansion of the MHC gene family, associated autoimmunity trade-offs, hitchhiking of deleterious mutations linked to the MHC, geographic subdivision, and adaptive introgression.

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Language(s): eng - English
 Dates: 2020-02-072020-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.tig.2020.01.008
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 36 (4) Sequence Number: - Start / End Page: 298 - 311 Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719