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  Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

Morimoto, R., O’Meara, C. P., Holland, S. J., Trancoso, I., Souissi, A., Schorpp, M., et al. (2020). Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys. Science Immunology, 5: eaba0925. doi:10.1126/sciimmunol.aba0925.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-0AA0-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-065A-C
Genre: Journal Article

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Morimoto et al..pdf (Publisher version), 3MB
 
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2020
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https://immunology.sciencemag.org/content/5/45/eaba0925.long (Publisher version)
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 Creators:
Morimoto, Ryo1, Author           
O’Meara, Connor P.1, Author
Holland, Stephen J.1, Author
Trancoso, I.1, Author           
Souissi, Ahmed2, Author
Schorpp, Michael1, Author           
Vassaux, Danièle2, Author
Iwanami, Norimasa1, Author
Giorgetti, Orlando Bruno1, Author           
Evanno, Guillaume2, Author
Boehm, Thomas1, Author           
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2External Organizations, ou_persistent22              

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 Abstract: The antibodies of jawless vertebrates consist of leucine-rich repeat arrays encoded by somatically assembled VLRB genes. It is unknown how the incomplete germline VLRB loci are converted into functional antibody genes during B lymphocyte development in lampreys. In Lampetra planeri larvae lacking the cytidine deaminase CDA2 gene, VLRB assembly fails, whereas the T lineage-associated VLRA and VLRC antigen receptor gene assemblies occur normally. Thus, CDA2 acts in a B cell lineage-specific fashion to support the somatic diversification of VLRB antibody genes. CDA2 is closely related to activation-induced cytidine deaminase (AID), which is essential for the elaboration of immunoglobulin gene repertoires in jawed vertebrates. Our results thus identify a convergent mechanism of antigen receptor gene assembly and diversification that independently evolved in the two sister branches of vertebrates.

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Language(s): eng - English
 Dates: 2020-03-132020-03-27
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1126/sciimmunol.aba0925
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Title: Science Immunology
  Abbreviation : Sci Immunol .
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: eaba0925 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/2470-9468