English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Temporal Integration in Visual Cortex of Cats with Surgically Induced Strabismus

Eschweiler, G., & Rauschecker, J. (1993). Temporal Integration in Visual Cortex of Cats with Surgically Induced Strabismus. European Journal of Neuroscience, 5(11), 1501-1509. doi:10.1111/j.1460-9568.1993.tb00218.x.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-02C2-C Version Permalink: http://hdl.handle.net/21.11116/0000-0006-02C3-B
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Eschweiler, GW1, 2, Author              
Rauschecker, JP1, 2, Author              
Affiliations:
1Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497803              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Single unit response latencies in striate cortex after visual stimulation with stationary flashed bars were measured and interocularly compared in anaesthetized cats with surgically induced strabismus, in order to elucidate the neural basis of strabismic amblyopia. Four unilateral esotropic and two exotropic cats were studied. The visual onset latencies of cortical neurons ranged from 30 to 170 ms after stimulation of the non‐deviating eye at a contrast of 82%. Responses after visual stimulation of the deviating eye were consistently delayed by ∼10 ms. The latency increase was independent of the direction and absolute angle of squint in the different animals. Peak latencies of cortical neurons ranged from 43 to 245 ms. Median peak latency was 85 ms for the non‐deviating and 95 ms for the deviating eye. The rise time of cortical flash responses, as determined from onset ‐ peak differences, ranged between 2 and 170 ms. Direct interocular comparison of response latencies in the remaining binocular neurons revealed an invariable advantage for the non‐deviating eye. Supragranular neurons showed a greater interocular latency difference than neurons in layer IV. Visual latencies were contrast‐dependent. However, the latency reduction with increasing contrast was less pronounced for the deviating eye. We discuss the possibility that central integration times, especially within cortex, are prolonged in strabismic cats, affecting temporal coincidence of signal processing in the visual cortex. The resulting disturbance of spatio‐temporal integration, as caused by a scrambling of geniculo‐striate and intracortical connections, may be the substrate of binocular suppression and strabismic amblyopia.

Details

show
hide
Language(s):
 Dates: 1993-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Neuroscience
  Other : Eur. J. Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 5 (11) Sequence Number: - Start / End Page: 1501 - 1509 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988