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  Alternative polyadenylation couples to transcription initiation: Insights from ELAV-mediated 3' UTR extension

Hilgers, V. (2015). Alternative polyadenylation couples to transcription initiation: Insights from ELAV-mediated 3' UTR extension. RNA Biology, 12, 918-921. doi:10.1080/15476286.2015.1060393.

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Hilgers et al..pdf (Publisher version), 568KB
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Hilgers, Valérie1, Author              
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1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              

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Free keywords: 3′ UTR extension; ELAV; alternative polyadenylation; cleavage and polyadenylation; drosophila; nervous system; pol II pausing; promoter; transcription initiation
 Abstract: Transcription initiation and mRNA maturation were long considered co-occurring but separately regulated events of gene control. In the past decade, gene promoters, the platforms of transcription initiation, have been assigned additional functions such as the regulation of splicing and 3' end processing. In a recent study, Oktaba and Zhang and al. reveal that neural 3' UTR extension is dependent on promoter sequences. In Drosophila neurons, promoter regions of a subset of genes recruit the RNA-binding protein ELAV, which is required for subsequent ELAV-mediated alternative polyadenylation. Intriguingly, RNA Polymerase II pausing at promoters seems to facilitate ELAV recruitment. How transcription initiation and alternative polyadenylation, processes separated by an entire gene length, are functionally linked, remains unsolved. In this article, I summarize recent findings and discuss possible mechanisms.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/15476286.2015.1060393
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Title: RNA Biology
Source Genre: Journal
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Publ. Info: Georgetown, TX : Landes Bioscience
Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: 918 - 921 Identifier: ISSN: 1547-6286
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021460