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  Ketamine-xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex

Rauschecker, J., & Hahn, S. (1987). Ketamine-xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex. Nature, 326(6109), 183-185. doi:10.1038/326183a0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-02E8-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-02E9-1
Genre: Journal Article

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https://www.nature.com/articles/326183a0.pdf (Publisher version)
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 Creators:
Rauschecker, JP1, 2, Author              
Hahn, S1, 2, Author              
Affiliations:
1Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497803              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: In the visual cortex of mammals, response properties of single neurons can be changed by restricted visual experience during early postnatal development1. Covering one eye for four to eight hours when kittens are at the peak of the sensitive period is sufficient to weaken the influence of the occluded eye on cortical neurons resulting in a noticeable shift of ocular dominance towards the open eye2–5. The underlying changes in synaptic connections do not occur so readily when a kitten is anaesthetized and paralysed6–8. We report here that an ocular dominance shift is prevented in alert kittens that receive repeated brief monocular exposures when these are followed by ketamine–xylazine anaesthesia. This retrograde effect on cortical plasticity suggests that the process by which synaptic activity is converted into structural changes has been disturbed.

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 Dates: 1987-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/326183a0
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 326 (6109) Sequence Number: - Start / End Page: 183 - 185 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238