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  ELAV mediates 3' UTR extension in the Drosophila nervous system

Hilgers, V., Lemke, S. B., & Levine, M. (2012). ELAV mediates 3' UTR extension in the Drosophila nervous system. Proceedings of the National Academy of Sciences of the United States of America, 26, 2259-2264. doi:10.1101/gad.199653.112.

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Hilgers et al. 2.pdf (Publisher version), 997KB
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Hilgers, Valérie1, Author              
Lemke, Sandra B.2, Author
Levine, Michael2, Author
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1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              
2External Organizations, ou_persistent22              

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 Abstract: Post-transcriptional gene regulation is prevalent in the nervous system, where multiple tiers of regulatory complexity contributeto the development and function of highly specialized cell types. Whole-genome studies in Drosophila have identified several hundred genes containing long 3′ extensions in neural tissues. We show that ELAV (embryonic-lethalabnormal visual system) is a key mediator of these neural-specific extensions. Misexpression of ELAV results in the ectopicsynthesis of long messenger RNAs (mRNAs) in transgenic embryos. RNA immunoprecipitation assays suggest that ELAV directlybinds the proximal polyadenylation signals of many target mRNAs. Finally, ELAV is sufficient to suppress 3′ end formationat a strong polyadenylation signal when tethered to a synthetic RNA. We propose that this mechanism for coordinating 3′ UTRextension may be generally used in a variety of cellular processes.

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Language(s): eng - English
 Dates: 2012-10-15
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1101/gad.199653.112
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 26 Sequence Number: - Start / End Page: 2259 - 2264 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230