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  The mechanics of myeloid cells

Bashant, K. R., Toepfner, N., Day, C. J., Mehta, N. N., Kaplan, M. J., Summers, C., et al. (2020). The mechanics of myeloid cells. Biology of the Cell, 112, 103-112. doi:10.1111/boc.201900084.

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 Urheber:
Bashant, Kathleen R.1, Autor
Toepfner, Nicole2, Autor
Day, Christopher J.1, Autor
Mehta, Nehal N.1, Autor
Kaplan, Mariana J.1, Autor
Summers, Charlotte1, Autor
Guck, Jochen3, 4, Autor           
Chilvers, Edwin A1, Autor
Affiliations:
1external, ou_persistent22              
2Center for Molecular and Cellular Bioengineering, Biotechnology Center, Technische Universität Dresden, Tatzberg 47-49, 01307 Dresden, Germany, ou_persistent22              
3Max Planck Institute for the Science of Light, Max Planck Society, Staudtstraße 2, 91058 Erlangen, DE, ou_2355696              
4Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              

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 Zusammenfassung: The effects of cell size, shape and deformability on cellular function have long been a topic of interest. Recently, mechanical phenotyping technologies capable of analysing large numbers of cells in real time have become available. This has important implications for biology and medicine, especially haemato‐oncology and immunology, as immune cell mechanical phenotyping, immunologic function, and malignant cell transformation are closely linked and potentially exploitable to develop new diagnostics and therapeutics. In this review, we introduce the technologies used to analyse cellular mechanical properties and review emerging findings following the advent of high throughput deformability cytometry. We largely focus on cells from the myeloid lineage, which are derived from the bone marrow and include macrophages, granulocytes and erythrocytes. We highlight advances in mechanical phenotyping of cells in suspension that are revealing novel signatures of human blood diseases and providing new insights into pathogenesis of these diseases. The contributions of mechanical phenotyping of cells in suspension to our understanding of drug mechanisms, identification of novel therapeutics and monitoring of treatment efficacy particularly in instances of haematologic diseases are reviewed, and we suggest emerging topics of study to explore as high throughput deformability cytometers become prevalent in laboratories across the globe.

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Sprache(n): eng - English
 Datum: 2020-01-032020-01-09
 Publikationsstatus: Online veröffentlicht
 Seiten: 9
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1111/boc.201900084
 Art des Abschluß: -

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Titel: Biology of the Cell
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New Jersey, USA : Wiley
Seiten: - Band / Heft: 112 Artikelnummer: - Start- / Endseite: 103 - 112 Identifikator: ISSN: 0248-4900 
ISSN: 1768-322X