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  Neural-specific elongation of 3' UTRs during Drosophila development

Hilgers, V., Perry, M. W., Hendrix, D., Stark, A., Levine, M., & Haley, B. (2011). Neural-specific elongation of 3' UTRs during Drosophila development. Proceedings of the National Academy of Sciences of the United States of America, 108, 15864-15869. doi:10.1073/pnas.1112672108.

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https://www.pnas.org/content/108/38/15864.long (Publisher version)
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 Creators:
Hilgers, Valérie1, Author              
Perry, Michael W.2, Author
Hendrix, David2, Author
Stark, Alexander2, Author
Levine, Michael2, Author
Haley, Benjamin2, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              
2External Organizations, ou_persistent22              

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Free keywords: posttranscriptional process, maternal-to-zygotic transition, nervous system, alternative polyadenylation
 Abstract: The 3′ termini of eukaryotic mRNAs influence transcript stability, translation efficiency, and subcellular localization. Here we report that a subset of developmental regulatory genes, enriched in critical RNA-processing factors, exhibits synchronous lengthening of their 3′ UTRs during embryogenesis. The resulting UTRs are up to 20-fold longer than those found on typical Drosophila mRNAs. The large mRNAs emerge shortly after the onset of zygotic transcription, with several of these genes acquiring additional, phased UTR extensions later in embryogenesis. We show that these extended 3′ UTR sequences are selectively expressed in neural tissues and contain putative recognition motifs for the translational repressor, Pumilio, which also exhibits the 3′ lengthening phenomenon documented in this study. These findings suggest a previously unknown mode of posttranscriptional regulation that may contribute to the complexity of neurogenesis or neural function.

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Language(s): eng - English
 Dates: 2011-09-20
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.1112672108
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 108 Sequence Number: - Start / End Page: 15864 - 15869 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230