English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis

Hilgers, V., Bushati, N., & Cohen, S. M. (2010). Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biology, 8, e1000396. doi:10.1371/journal.pbio.1000396.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Hilgers et al..pdf (Publisher version), 666KB
Name:
Hilgers et al..pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Hilgers, Valérie1, Author              
Bushati, Natascha2, Author
Cohen, Stephen M.2, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. Both microRNAs are expressed in the bristle progenitors, and despite a difference in their seed sequence, they share this key common target. In miR-263a and miR-263b deletion mutants, loss of bristles appears to be sporadic, suggesting that the role of the microRNAs may be to ensure robustness of the patterning process by promoting survival of these functionally specified cells. In the context of the retina, this mechanism ensures that the interommatidial bristles are protected during the developmentally programmed wave of cell death that prunes excess cells in order to refine the pattern of the pupal retina.

Details

show
hide
Language(s): eng - English
 Dates: 2010-06-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pbio.1000396
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 8 Sequence Number: - Start / End Page: e1000396 Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170