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  Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception

Denzel, D., Colic, L., Demenescu, R., von Düring, F., Ristow, I., Nießen, H., et al. (2020). Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception. European Journal of Neuroscience, 52(3), 3047-3060. doi:10.1111/ejn.14733.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-0707-B Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D0B1-6
Genre: Journal Article

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 Creators:
Denzel, D, Author
Colic, L, Author
Demenescu, RL, Author
von Düring, F, Author
Ristow, I, Author
Nießen, H, Author
Hermann, L, Author
Kaufmann, J, Author
Dannlowski, U, Author
Frommer, J, Author
Vogel, M, Author
Li, M1, 2, Author              
Lord, A, Author
Walter, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The cingulate cortex is involved in emotion recognition / perception and regulation. Rostral and caudal subregions belong to different brain networks with distinct roles in affective perception. Despite recent accounts of the relevance of cingulate cortex glutamate (Glu) on blood oxygenation level dependent (BOLD) responses, the specificity of the subregional Glu levels during emotional tasks remains unclear. Seventy-two healthy participants (age= 27.33± 6.67, 32 women) performed an affective face-matching task and underwent magnetic resonance spectroscopy (MRS) at 7 Tesla. Correlations between the BOLD response during emotion perception and Glu concentration in the pregenual anterior cingulate cortex (pgACC) and anterior midcingulate cortex (aMCC) were compared on a whole brain level. Post hoc specificity of the association with an affect was assessed. Lower Glu in the pgACC correlated with stronger activation differences between negative and positive faces in the left inferior and superior frontal gyrus (L IFG and L SFG). In contrast, lower Glu in the aMCC correlated with BOLD contrasts in the posterior cingulate cortex (PCC). Furthermore, negative face detection was associated with prolonged response time (RT). Our results demonstrate a subregion-specific involvement of cingulate cortex Glu in interindividual differences during viewing of affective facial expressions. Glu levels in the pgACC were correlated with frontal area brain activations, whereas Glu in the salience network component aMCC modulated responses in the PCC-Precuneus. We show that region specific metabolite mapping enables specific activation of different BOLD signals in the brain underlying emotional perception.

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 Dates: 2020-042020-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/ejn.14733
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Title: European Journal of Neuroscience
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 52 (3) Sequence Number: - Start / End Page: 3047 - 3060 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988