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  Local translation in neurons: visualization and function

Holt, C., Martin, K. C., & Schuman, E. M. (2019). Local translation in neurons: visualization and function. Nature Structural and Molecular Biology, 26(7), 557-566. doi:10.1038/s41594-019-0263-5.

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 Creators:
Holt, Christine1, Author              
Martin, Kelsey C.2, Author              
Schuman, Erin M.3, Author              
Affiliations:
1Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK, ou_persistent22              
2Department of Biological Chemistry and Department of Psychiatry and Behavioral Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA, ou_persistent22              
3Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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 Abstract: Neurons are among the most compartmentalized and interactive of all cell types. Like all cells, neurons use proteins as the main sensors and effectors. The modification of the proteome in axons and dendrites is used to guide the formation of synaptic connections and to store information. In this Review, we discuss the data indicating that an important source of protein for dendrites, axons and their associated elements is provided by the local synthesis of proteins. We review the data indicating the presence of the machinery required for protein synthesis, the direct visualization and demonstration of protein synthesis, and the established functional roles for local translation for many different neuronal functions. Finally, we consider the open questions and future directions in this field.

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 Dates: 2019-07-03
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41594-019-0263-5
PMID: 31270476
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Title: Nature Structural and Molecular Biology
  Other : Nature Struct Biol
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 557 - 566 Identifier: ISSN: 1545-9993
CoNE: https://pure.mpg.de/cone/journals/resource/954925603763