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  Larval zebrafish proteome regulation in response to an environmental challenge

Langebeck-Jensen, K., Shahar, O. D., Schuman, E. M., Langer, J. D., & Ryu, S. (2019). Larval zebrafish proteome regulation in response to an environmental challenge. Proteomics, 19: 1900028. doi:10.1002/pmic.201900028.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-E068-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-8330-B
Genre: Journal Article

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Proteomics - 2019 - Langebeck%u2010Jensen - Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge.pdf (Publisher version), 2MB
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Proteomics - 2019 - Langebeck%u2010Jensen - Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge.pdf
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2019
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https://pubmed.ncbi.nlm.nih.gov/31168896/ (Any fulltext)
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 Creators:
Langebeck-Jensen, Kaspar1, Author           
Shahar, Or D.1, Author           
Schuman, Erin M.1, Author           
Langer, Julian D.2, Author           
Ryu, Soojin3, Author           
Affiliations:
1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              
2Proteomics and Mass Spectrometry, Max Planck Institute of Biophysics, Max Planck Society, ou_3262216              
3Developmental Neurobiology of Resilience, University of Mainz Medical Center, Johannes Gutenberg University of Mainz, ou_persistent22              

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Free keywords: adaptation; brain; environmental challenge; proteomics; zebrafish.
 Abstract: Adaptation to the environment during development influences the life‐long survival of an animal. While brain‐wide proteomic changes are expected to underlie such experience‐driven physiological and behavioral flexibility, a comprehensive overview of the nature and extent of the proteomic regulation following an environmental challenge during development is currently lacking. In this study, the brain proteome of larval zebrafish is identified and it is determined how it is altered by an exposure to a natural and physical environmental challenge, namely prolonged exposure to strong water currents. A comprehensive larval zebrafish brain proteome is presented here. Furthermore, 57 proteins that are regulated by the exposure to an environmental challenge are identified, which cover multiple functions including neuronal plasticity, the stress response, axonal growth and guidance, spatial learning, and energy metabolism. These represent candidate proteins that may play crucial roles for the adaption to an environmental challenge during development.

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 Dates: 2019-01-162019-06-06
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/pmic.201900028
 Degree: -

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Project name : ERC-AdG NeuroRibo
Grant ID : 743216
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis (Subproject B01)
Grant ID : 221828878
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention (Subproject A04)
Grant ID : 264810226
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : SFB 902: Molecular Principles of RNA-based Regulation
Grant ID : 161793742
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Proteomics
Source Genre: Journal
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Publ. Info: Weinheim : WILEY-VCH
Pages: - Volume / Issue: 19 Sequence Number: 1900028 Start / End Page: - Identifier: ISSN: 1615-9853
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000294310