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  Differential DNA methylation of vocal and facial anatomy genes in modern humans

Gokhman, D., Nissim-Rafinia, M., Agranat-Tamir, L., Housman, G., García-Pérez, R., Lizano, E., et al. (2020). Differential DNA methylation of vocal and facial anatomy genes in modern humans. Nature Communications, 11: 1189. doi:10.1038/s41467-020-15020-6.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-0A30-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-0A31-8
Genre: Journal Article

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 Creators:
Gokhman, David , Author
Nissim-Rafinia, Malka , Author
Agranat-Tamir, Lily , Author
Housman, Genevieve , Author
García-Pérez, Raquel , Author
Lizano, Esther , Author
Cheronet, Olivia , Author
Mallick, Swapan , Author
Nieves-Colón, Maria A. , Author
Li, Heng, Author
Alpaslan-Roodenberg, Songül , Author
Novak, Mario , Author
Gu, Hongcang , Author
Osinski, Jason M. , Author
Ferrando-Bernal, Manuel , Author
Gelabert, Pere , Author
Lipende, Iddi , Author
Mjungu, Deus , Author
Kondova, Ivanela , Author
Bontrop, Ronald , Author
Kullmer, Ottmar , AuthorWeber, Gerhard , AuthorShahar, Tal , AuthorDvir-Ginzberg, Mona , AuthorFaerman, Marina , AuthorQuillen, Ellen E. , AuthorMeissner, Alexander1, Author              Lahav, Yonatan , AuthorKandel, Leonid , AuthorLiebergall, Meir , AuthorPrada, María E. , AuthorVidal, Julio M. , AuthorGronostajski, Richard M. , AuthorStone, Anne C. , AuthorYakir, Benjamin , AuthorLalueza-Fox, Carles , AuthorPinhasi, Ron , AuthorReich, David , AuthorMarques-Bonet, Tomas , AuthorMeshorer, Eran , AuthorCarmel, Liran , Author more..
Affiliations:
1Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              

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 Abstract: Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract.

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Language(s): eng - English
 Dates: 2020-02-132020-03-04
 Publication Status: Published online
 Pages: -
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 Identifiers: DOI: 10.1038/s41467-020-15020-6
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 11 Sequence Number: 1189 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723