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  Formation of target-specific neuronal projections in organotypic slice cultures from rat visual cortex

Bolz, J., Novak, N., Götz, M., & Bonhoeffer, T. (1990). Formation of target-specific neuronal projections in organotypic slice cultures from rat visual cortex. Nature, 346(6282), 359-362. doi:10.1038/346359a0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-0C2B-E Version Permalink: http://hdl.handle.net/21.11116/0000-0006-0C2C-D
Genre: Journal Article

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https://www.nature.com/articles/346359a0.pdf (Publisher version)
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 Creators:
Bolz, J1, Author
Novak, N1, Author
Götz, M1, Author
Bonhoeffer, T2, 3, Author              
Affiliations:
1Friedrich Miescher Laboratory, Max Planck Society, Max-Planck-Ring 9, 72076 Tübingen, DE, ou_2575692              
2Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497803              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A characteristic feature of the mammalian cortex is that projection neurons located in distinct cortical layers send their axons to different targets. In visual cortex, cells in layers 2 and 3 project to other cortical areas, whereas cells in layers 5 and 6 project to subcortical targets such as the lateral geniculate nucleus. The proper development of these projections is crucial for correct functioning of the visual system. Here we show that specific connections are established in an organotypic culture system in which rat visual cortex slices are co-cultured with another slice of the visual cortex or with a thalamic slice. The laminar origin and cellular morphology in vitro of cortical projections to other cortical regions or to subcortical targets are remarkably similar to those seen in vivo. In addition, axons of projecting cells are not restricted to particular pathways, but appear instead to grow directly towards their appropriate target. These observations raise the possibility that chemotropic attraction from the target areas may play an important part in the development of the cortical projection pattern.

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 Dates: 1990-07
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/346359a0
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 346 (6282) Sequence Number: - Start / End Page: 359 - 362 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238