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  Non-Hebbian synapses in rat visual cortex

Kossel, A., Bonhoeffer, T., & Bolz, J. (1990). Non-Hebbian synapses in rat visual cortex. NeuroReport, 1(2), 115-118. doi:10.1097/00001756-199010000-00008.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-0C32-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-3A44-D
Genre: Journal Article

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Kossel, A1, Author              
Bonhoeffer, T2, 3, Author              
Bolz, J1, Author
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1Friedrich Miescher Laboratory, Max Planck Society, Max-Planck-Ring 9, 72076 Tübingen, DE, ou_2575692              
2Former Department Structure and Function of Natural Nerve-Net , Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497803              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: In the mammalian CNS, long term potentiation can be induced by repeatedly pairing presynaptic stimulation with postsynaptic depolarization of a single cell, similar to a model proposed by Hebb, that synaptic strengthening occurs as a result of correlated pre- and postsynaptic activity. However, our experiments indicate that the Hebbian rule is not strictly valid in the cortex. Double intracellular recordings showed that synaptic reinforcement is not confined to the depolarized postsynaptic neuron, but is also observed in adjacent but not coactivated neurons. The enhancement and its spread is stimulus-specific, it occurs only for fibres stimulated during the pairing procedure. During development, this spread might lead to a characteristic organizing principle of the cortex, the clustering of cells with similar functional properties.

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 Dates: 1990-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1097/00001756-199010000-00008
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Title: NeuroReport
Source Genre: Journal
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Publ. Info: Oxford, UK : Rapid Communications of Oxford Ltd.
Pages: - Volume / Issue: 1 (2) Sequence Number: - Start / End Page: 115 - 118 Identifier: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070