English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The role of the pre-commissural fornix in episodic autobiographical memory and simulation

Williams, A. N., Ridgeway, S., Postans, M., Graham, K. S., Lawrence, A. D., & Hodgetts, C. J. (2020). The role of the pre-commissural fornix in episodic autobiographical memory and simulation. Neuropsychologia, 142: 107457. doi:10.1016/j.neuropsychologia.2020.107457.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-0D0E-E Version Permalink: http://hdl.handle.net/21.11116/0000-0006-B301-E
Genre: Journal Article

Files

show Files
hide Files
:
Williams_2020.pdf (Publisher version), 3MB
Name:
Williams_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Williams, Angharad N.1, 2, Author              
Ridgeway, Samuel1, Author
Postans, Mark1, Author
Graham, Kim S.1, Author
Lawrence, Andrew D.1, Author
Hodgetts, Carl J.1, 3, Author
Affiliations:
1Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom, ou_persistent22              
2Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691              
3Department of Psychology, Royal Holloway University of London, United Kingdom, ou_persistent22              

Content

show
hide
Free keywords: Hippocampus; Episodic memory; Future thinking; Mental time travel; vmPFC; White matter tractography
 Abstract: Neuropsychological and functional magnetic resonance imaging (MRI) evidence suggests that the ability to vividly remember our personal past, and imagine future scenarios, involves two closely connected regions: the hippocampus and ventromedial prefrontal cortex (vmPFC). Despite evidence of a direct anatomical connection from hippocampus to vmPFC, it is unknown whether hippocampal-vmPFC structural connectivity supports both past and future-oriented episodic thinking. To address this, we applied diffusion-weighted magnetic resonance imaging (dMRI) and a novel deterministic tractography protocol to reconstruct distinct subdivisions of the fornix previously detected in axonal tracer studies, namely pre-commissural (connecting the hippocampus to vmPFC) and post-commissural (linking the hippocampus and medial diencephalon) fornix, in a group of healthy young adult humans who undertook an adapted past-future autobiographical interview (portions of this data were published in Hodgetts et al., 2017). As predicted, we found that inter-individual differences in pre-commissural - but not post-commissural - fornix microstructure (fractional anisotropy) were significantly correlated with the episodic richness of both past and future autobiographical narratives. Notably, these results remained significant when controlling for non-episodic narrative content, verbal fluency, and grey matter volumes of the hippocampus and vmPFC. This study provides novel evidence that reconstructing events from one's personal past, and constructing possible future events, involves a distinct, structurally-instantiated hippocampal-vmPFC pathway.

Details

show
hide
Language(s): eng - English
 Dates: 2020-03-252019-12-132020-03-302020-04-042020-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuropsychologia.2020.107457
Other: Epub ahead of print
PMID: 32259556
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuropsychologia
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 142 Sequence Number: 107457 Start / End Page: - Identifier: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258