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  The dental proteome of Homo antecessor

Welker, F., Ramos-Madrigal, J., Gutenbrunner, P., Mackie, M., Tiwary, S., Jersie-Christensen, R. R., et al. (2020). The dental proteome of Homo antecessor. NATURE. doi:10.1038/s41586-020-2153-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-10D3-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-10D4-8
Genre: Journal Article

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 Creators:
Welker, Frido1, Author
Ramos-Madrigal, Jazmin1, Author
Gutenbrunner, Petra2, Author              
Mackie, Meaghan1, Author
Tiwary, Shivani2, Author              
Jersie-Christensen, Rosa Rakownikow1, Author
Chiva, Cristina1, Author
Dickinson, Marc R.1, Author
Kuhlwilm, Martin1, Author
de Manuel, Marc1, Author
Gelabert, Pere1, Author
Martinon-Torres, Maria1, Author
Margvelashvili, Ann1, Author
Arsuaga, Juan Luis1, Author
Carbonell, Eudald1, Author
Marques-Bonet, Tomas1, Author
Penkman, Kirsty1, Author
Sabido, Eduard1, Author
Cox, Juergen2, Author              
Olsen, Jesper V.1, Author
Lordkipanidze, David1, AuthorRacimo, Fernando1, AuthorLalueza-Fox, Carles1, Authorde Castro, Jose Maria Bermudez1, AuthorWillerslev, Eske1, AuthorCappellini, Enrico1, Author more..
Affiliations:
1external, ou_persistent22              
2Cox, Jürgen / Computational Systems Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_2063284              

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Free keywords: MIDDLE PLEISTOCENE; GENOME SEQUENCE; DIVERSITY; PROTEINS; DMANISI; ENAMEL; SITE; IDENTIFICATION; NEANDERTHAL; EVOLUTION
 Abstract: Analyses of the proteomes of dental enamel from Homo antecessor and Homo erectus demonstrate that the Early Pleistocene H. antecessor is a close sister lineage of later Homo sapiens, Neanderthal and Denisovan populations in Eurasia. The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo sapiens, are highly debated(1-5). For the oldest remains, the molecular study of these relationships is hindered by the degradation of ancient DNA. However, recent research has demonstrated that the analysis of ancient proteins can address this challenge(6-8). Here we present the dental enamel proteomes of H. antecessor from Atapuerca (Spain)(9,10) and Homo erectus from Dmanisi (Georgia)(1), two key fossil assemblages that have a central role in models of Pleistocene hominin morphology, dispersal and divergence. We provide evidence that H. antecessor is a close sister lineage to subsequent Middle and Late Pleistocene hominins, including modern humans, Neanderthals and Denisovans. This placement implies that the modern-like face of H. antecessor-that is, similar to that of modern humans-may have a considerably deep ancestry in the genus Homo, and that the cranial morphology of Neanderthals represents a derived form. By recovering AMELY-specific peptide sequences, we also conclude that the H. antecessor molar fragment from Atapuerca that we analysed belonged to a male individual. Finally, these H. antecessor and H. erectus fossils preserve evidence of enamel proteome phosphorylation and proteolytic digestion that occurred in vivo during tooth formation. Our results provide important insights into the evolutionary relationships between H. antecessor and other hominin groups, and pave the way for future studies using enamel proteomes to investigate hominin biology across the existence of the genus Homo.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 21
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000522805400006
DOI: 10.1038/s41586-020-2153-8
 Degree: -

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Title: NATURE
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0028-0836