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  Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents

Dobrynin, S., Kutseikin, S., Morozov, D., Krumkacheva, O., Spitsyna, A., Gatilov, Y., et al. (2020). Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents. Molecules, 25(7): 1709, pp. 1-15. doi:10.3390/molecules25071709.

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https://www.mdpi.com/1420-3049/25/7/1709 (Publisher version)
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 Creators:
Dobrynin, S, Author
Kutseikin, S, Author
Morozov, D, Author
Krumkacheva, O, Author
Spitsyna, A, Author
Gatilov, Y, Author
Silnikov, V, Author
Angelovski, G1, 2, Author              
Bowman, MK, Author
Kirilyuk, I, Author
Chubarov, A, Author
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates and are much greater than those of their individual components: the HSA or the small nitroxide molecules. This new family of conjugates has excellent prospects for optimization as ORCAs

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 Dates: 2020-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/molecules25071709
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Title: Molecules
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 25 (7) Sequence Number: 1709 Start / End Page: 1 - 15 Identifier: ISSN: 1420-3049
CoNE: https://pure.mpg.de/cone/journals/resource/954925623244