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  Lasting organ-level bone mechanoadaptation is unrelated to local strain

Javaheri, B., Razi, H., Gohin, S., Wylie, S., Chang, Y.-M., Salmon, P., et al. (2020). Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances, 6(10): eaax8301. doi:10.1126/sciadv.aax8301.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-32ED-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-32EE-6
Genre: Journal Article

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 Creators:
Javaheri, Behzad, Author
Razi, Hajar1, Author              
Gohin, Stephanie, Author
Wylie, Sebastian, Author
Chang, Yu-Mei, Author
Salmon, Phil, Author
Lee, Peter D., Author
Pitsillides, Andrew A., Author
Affiliations:
1Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863285              

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 Abstract: Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and remodeling in vivo. We first confirmed that some acute load-induced structural changes are reversible, adhere to the linear strain magnitude regulation of remodeling activities, and are restricted to bone regions in which marked antiresorptive actions are evident. We make the novel observation that loading exerts significant lasting modifications in tibial shape and mass across extensive bone regions, underpinned by (re)modeling independent of local strain magnitude, occurring at sites where the initial response to load is principally osteogenic. This is the first report to demonstrate that bone loading stimulates nonlinear remodeling responses to strain that culminate in greater curvature adjusted for load predictability without sacrificing strength.

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Language(s): eng - English
 Dates: 2020-03-062020
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1126/sciadv.aax8301
BibTex Citekey: Javaherieaax8301
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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 6 (10) Sequence Number: eaax8301 Start / End Page: - Identifier: ISSN: 2375-2548