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  Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively

Ponce-Alvarez, A., Mochol, G., Hermoso-Mendizabal, A., de la Rocha, J., & Deco, G. (2020). Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively. eLife, 9: e53268. doi:10.7554/eLife.53268.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0006-3E47-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-32AB-A
Genre: Zeitschriftenartikel

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 Urheber:
Ponce-Alvarez, Adrian1, Autor
Mochol, Gabriela1, Autor
Hermoso-Mendizabal, Ainhoa2, Autor
de la Rocha, Jaime2, Autor
Deco, Gustavo1, 3, 4, 5, Autor           
Affiliations:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ou_persistent22              
3Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Schlagwörter: Cortical states; Maximum entropy; Network topology; Neuroscience; Rat; Sloppiness; Spontaneous activity; Stimulus response
 Zusammenfassung: Previous research showed that spontaneous neuronal activity presents sloppiness: the collective behavior is strongly determined by a small number of parameter combinations, defined as ‘stiff’ dimensions, while it is insensitive to many others (‘sloppy’ dimensions). Here, we analyzed neural population activity from the auditory cortex of anesthetized rats while the brain spontaneously transited through different synchronized and desynchronized states and intermittently received sensory inputs. We showed that cortical state transitions were determined by changes in stiff parameters associated with the activity of a core of neurons with low responses to stimuli and high centrality within the observed network. In contrast, stimulus-evoked responses evolved along sloppy dimensions associated with the activity of neurons with low centrality and displaying large ongoing and stimulus-evoked fluctuations without affecting the integrity of the network. Our results shed light on the interplay among stability, flexibility, and responsiveness of neuronal collective dynamics during intrinsic and induced activity.

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Sprache(n): eng - English
 Datum: 2019-11-012020-03-162020-03-31
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.7554/eLife.53268
PMID: 32181740
PMC: PMC7108864
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : Flag-Era JTC PCI2018-092891
Förderprogramm : -
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : IJCI-2014-21937; BES-2011-049131; SAF2010-15730; SAF2013-46717-R; PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Ministerio de Economía y Competitividad
Projektname : -
Grant ID : SAF2013-46717-R; SAF2010-15730
Förderprogramm : -
Förderorganisation : European Regional Development Fund (ERDF)
Projektname : -
Grant ID : 785907 HBP SGA1 & 2
Förderprogramm : -
Förderorganisation : Horizon 2020 Framework Programme
Projektname : -
Grant ID : 2017 SGR 1545
Förderprogramm : -
Förderorganisation : Catalan Research Group Support

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Titel: eLife
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge : eLife Sciences Publications
Seiten: - Band / Heft: 9 Artikelnummer: e53268 Start- / Endseite: - Identifikator: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X