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  Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo

Stürner, T., Tatarnikova, A., Mueller, J., Schaffran, B., Cuntz, H., Zhang, Y., et al. (2019). Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development, 146(7): dev171397. doi:10.1242/dev.171397.

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Stürner_2019_TransientLocalization.pdf (Publisher version), 4MB
 
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2019
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Copyright © 2019. Published by The Company of Biologists Ltd
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 Creators:
Stürner, Tomke, Author
Tatarnikova, Anastasia, Author
Mueller, Jan, Author
Schaffran, Barbara, Author
Cuntz, Hermann1, 2, Author                 
Zhang, Yun, Author
Nemethova, Maria, Author
Bogdan, Sven, Author
Small, Vic, Author
Tavosanis, Gaia, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Cuntz Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381227              

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Free keywords: Actin Arp2/3 Dendrite Neuron Time-lapse imaging Wave
 Abstract: The formation of neuronal dendrite branches is fundamental for the wiring and function of the nervous system. Indeed, dendrite branching enhances the coverage of the neuron's receptive field and modulates the initial processing of incoming stimuli. Complex dendrite patterns are achieved in vivo through a dynamic process of de novo branch formation, branch extension and retraction. The first step towards branch formation is the generation of a dynamic filopodium-like branchlet. The mechanisms underlying the initiation of dendrite branchlets are therefore crucial to the shaping of dendrites. Through in vivo time-lapse imaging of the subcellular localization of actin during the process of branching of Drosophila larva sensory neurons, combined with genetic analysis and electron tomography, we have identified the Actin-related protein (Arp) 2/3 complex as the major actin nucleator involved in the initiation of dendrite branchlet formation, under the control of the activator WAVE and of the small GTPase Rac1. Transient recruitment of an Arp2/3 component marks the site of branchlet initiation in vivo These data position the activation of Arp2/3 as an early hub for the initiation of branchlet formation.

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 Dates: 2019-04-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1242/dev.171397
 Degree: -

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Title: Development
  Other : Development
Source Genre: Journal
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Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 146 (7) Sequence Number: dev171397 Start / End Page: - Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241