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  Mapping short association fibers in the early cortical visual processing stream using in vivo diffusion tractography

Attar, F. M., Kirilina, E., Haenelt, D., Pine, K., Trampel, R., Edwards, L., et al. (2020). Mapping short association fibers in the early cortical visual processing stream using in vivo diffusion tractography. Cerebral Cortex, 30(8), 4496-4514. doi:10.1093/cercor/bhaa049.

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Attar, Fakhereh Movahedian1, Autor           
Kirilina, Evgeniya1, 2, Autor           
Haenelt, Daniel1, Autor           
Pine, Kerrin1, Autor           
Trampel, Robert1, Autor           
Edwards, Luke1, Autor           
Weiskopf, Nikolaus1, 3, Autor           
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
3Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: U-fibers; Retinotopy; Subcortical; Submillimeter resolution; Superficial white matter
 Zusammenfassung: Short association fibers (U-fibers) connect proximal cortical areas and constitute the majority of white matter connections in the human brain. U-fibers play an important role in brain development, function, and pathology but are underrepresented in current descriptions of the human brain connectome, primarily due to methodological challenges in diffusion magnetic resonance imaging (dMRI) of these fibers. High spatial resolution and dedicated fiber and tractography models are required to reliably map the U-fibers. Moreover, limited quantitative knowledge of their geometry and distribution makes validation of U-fiber tractography challenging. Submillimeter resolution diffusion MRI-facilitated by a cutting-edge MRI scanner with 300 mT/m maximum gradient amplitude-was used to map U-fiber connectivity between primary and secondary visual cortical areas (V1 and V2, respectively) in vivo. V1 and V2 retinotopic maps were obtained using functional MRI at 7T. The mapped V1-V2 connectivity was retinotopically organized, demonstrating higher connectivity for retinotopically corresponding areas in V1 and V2 as expected. The results were highly reproducible, as demonstrated by repeated measurements in the same participants and by an independent replication group study. This study demonstrates a robust U-fiber connectivity mapping in vivo and is an important step toward construction of a more complete human brain connectome.

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Sprache(n): eng - English
 Datum: 2020-04-082020-08
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1093/cercor/bhaa049
PMID: 32297628
PMC: PMC7325803
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Projektname : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging / HMRI
Grant ID : 616905
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 01EW1711A; 01EW1711B
Förderprogramm : ERA-NET NEURON
Förderorganisation : German Federal Ministry of Education and Research (BMBF)

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Titel: Cerebral Cortex
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 30 (8) Artikelnummer: - Start- / Endseite: 4496 - 4514 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440