English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Breakdown of whole-brain dynamics in preterm-born children

Padilla, N., Saenger, V. M., van Hartevelt, T. J., Fernandes, H. M., Lennartsson, F., Andersson, J. L. R., et al. (2020). Breakdown of whole-brain dynamics in preterm-born children. Cerebral Cortex, 30(3), 1159-1170. doi:10.1093/cercor/bhz156.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-4357-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-4358-C
Genre: Journal Article

Files

show Files
hide Files
:
Padilla_2020.pdf (Publisher version), 2MB
Name:
Padilla_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Padilla, Nelly1, Author
Saenger, Victor M.2, Author
van Hartevelt, Tim J.3, 4, Author
Fernandes, Henrique M.3, 4, Author
Lennartsson, Finn1, 5, Author
Andersson, Jesper L. R.6, Author
Kringelbach, Morten3, 4, Author
Deco, Gustavo2, 7, 8, 9, Author              
Åden, Ulrika1, 10, Author
Affiliations:
1Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department of Psychiatry, Warneford Hospital, University of Oxford, United Kingdom, ou_persistent22              
4Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
5Department of Clinical Sciences, Lund University, Sweden, ou_persistent22              
6Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
7Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
8Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
9School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
10Department of Neonatology, Karolinska Institute, Stockholm, Sweden, ou_persistent22              

Content

show
hide
Free keywords: Brain development; Brain dynamics; Functional connectivity; Neurodevelopment; Prematurity
 Abstract: The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.

Details

show
hide
Language(s): eng - English
 Dates: 2019-06-182019-01-262019-06-202019-08-232020-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1093/cercor/bhz156
PMID: 31504269
PMC: PMC7132942
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 30 (3) Sequence Number: - Start / End Page: 1159 - 1170 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440