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  Genome-wide association study identifies 30 loci associated with bipolar disorder

Stahl, E. A., Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., et al. (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51(5), 793-+. doi:10.1038/s41588-019-0397-8.

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Stahl, Eli A., Author
Breen, Gerome, Author
Forstner, Andreas J., Author
McQuillin, Andrew, Author
Ripke, Stephan, Author
Trubetskoy, Vassily, Author
Mattheisen, Manuel, Author
Wang, Yunpeng, Author
Coleman, Jonathan R. I., Author
Gaspar, Helena A., Author
de Leeuw, Christiaan A., Author
Steinberg, Stacy, Author
Pavlides, Jennifer M. Whitehead, Author
Trzaskowski, Maciej, Author
Byrne, Enda M., Author
Pers, Tune H., Author
Holmans, Peter A., Author
Richards, Alexander L., Author
Abbott, Liam, Author
Agerbo, Esben, Author
Akil, Huda, AuthorAlbani, Diego, AuthorAlliey-Rodriguez, Ney, AuthorAls, Thomas D., AuthorAnjorin, Adebayo, AuthorAntilla, Verneri, AuthorAwasthi, Swapnil, AuthorBadner, Judith A., AuthorBaekvad-Hansen, Marie, AuthorBarchas, Jack D., AuthorBass, Nicholas, AuthorBauer, Michael, AuthorBelliveau, Richard, AuthorBergen, Sarah E., AuthorPedersen, Carsten Bocker, AuthorBoen, Erlend, AuthorBoks, Marco P., AuthorBoocock, James, AuthorBudde, Monika, AuthorBunney, William, AuthorBurmeister, Margit, AuthorBybjerg-Grauholm, Jonas, AuthorByerley, William, AuthorCasas, Miquel, AuthorCerrato, Felecia, AuthorCervantes, Pablo, AuthorChambert, Kimberly, AuthorCharney, Alexander W., AuthorChen, Danfeng, AuthorChurchhouse, Claire, AuthorClarke, Toni-Kim, AuthorCoryell, William, AuthorCraig, David W., AuthorCruceanu, Cristiana, AuthorCurtis, David, AuthorCzerski, Piotr M., AuthorDale, Anders M., Authorde Jong, Simone, AuthorDegenhardt, Franziska, AuthorDel-Favero, Jurgen, AuthorDePaulo, J. Raymond, AuthorDjurovic, Srdjan, AuthorDobbyn, Amanda L., AuthorDumont, Ashley, AuthorElvsashagen, Torbjorn, AuthorEscott-Price, Valentina, AuthorFan, Chun Chieh, AuthorFischer, Sascha B., AuthorFlickinger, Matthew, AuthorForoud, Tatiana M., AuthorForty, Liz, AuthorFrank, Josef, AuthorFraser, Christine, AuthorFreimer, Nelson B., AuthorFrisen, Louise, AuthorGade, Katrin, AuthorGage, Diane, AuthorGarnham, Julie, AuthorGiambartolomei, Claudia, AuthorPedersen, Marianne Giortz, AuthorGoldstein, Jaqueline, AuthorGordon, Scott D., AuthorGordon-Smith, Katherine, AuthorGreen, Elaine K., AuthorGreen, Melissa J., AuthorGreenwood, Tiffany A., AuthorGrove, Jakob, AuthorGuan, Weihua, AuthorGuzman-Parra, Jose, AuthorHamshere, Marian L., AuthorHautzinger, Martin, AuthorHeilbronner, Urs, AuthorHerms, Stefan, AuthorHipolito, Maria, AuthorHoffmann, Per, AuthorHolland, Dominic, AuthorHuckins, Laura, AuthorJamain, Stephane, AuthorJohnson, Jessica S., AuthorJureus, Anders, AuthorKandaswamy, Radhika, AuthorKarlsson, Robert, AuthorKennedy, James L., AuthorKittel-Schneider, Sarah, AuthorKnowles, James A., AuthorKogevinas, Manolis, AuthorKoller, Anna C., AuthorKupka, Ralph, AuthorLavebratt, Catharina, AuthorLawrence, Jacob, AuthorLawson, William B., AuthorLeber, Markus, AuthorLee, Phil H., AuthorLevy, Shawn E., AuthorLi, Jun Z., AuthorLiu, Chunyu, AuthorLucae, Susanne1, AuthorMaaser, Anna, AuthorMacIntyre, Donald J., AuthorMahon, Pamela B., AuthorMaier, Wolfgang, AuthorMartinsson, Lina, AuthorMcCarroll, Steve, AuthorMcGuffin, Peter, AuthorMcInnis, Melvin G., AuthorMckay, James D., AuthorMedeiros, Helena, AuthorMedland, Sarah E., AuthorMeng, Fan, AuthorMilani, Lili, AuthorMontgomery, Grant W., AuthorMorris, Derek W., AuthorMuhleisen, Thomas W., AuthorMullins, Niamh, AuthorNguyen, Hoang, AuthorNievergelt, Caroline M., AuthorAdolfsson, Annelie Nordin, AuthorNwulia, Evaristus A., AuthorO'Donovan, Claire, AuthorLoohuis, Loes M. Olde, AuthorOri, Anil P. S., AuthorOruc, Lilijana, AuthorOsby, Urban, AuthorPerlis, Roy H., AuthorPerry, Amy, AuthorAndrea, Pfennig, AuthorPotash, James B., AuthorPurcell, Shaun M., AuthorRegeer, Eline J., AuthorReif, Andreas, AuthorReinbold, Celine S., AuthorRice, John P., AuthorRivas, Fabio, AuthorRivera, Margarita, AuthorRoussos, Panos, AuthorRuderfer, Douglas M., AuthorRyu, Euijung, AuthorSanchez-Mora, Cristina, AuthorSchatzberg, Alan F., AuthorScheftner, William A., AuthorSchork, Nicholas J., AuthorWeickert, Cynthia Shannon, AuthorShehktman, Tatyana, AuthorShilling, Paul D., AuthorSigurdsson, Engilbert, AuthorSlaney, Claire, AuthorSmeland, Olav B., AuthorSobell, Janet L., AuthorHansen, Christine Soholm, AuthorSpijker, Anne T., AuthorSt Clair, David, AuthorSteffens, Michael, AuthorStrauss, John S., AuthorStreit, Fabian, AuthorStrohmaier, Jana, AuthorSzelinger, Szabolcs, AuthorThompson, Robert C., AuthorThorgeirsson, Thorgeir E., AuthorTreutlein, Jens, AuthorVedder, Helmut, AuthorWang, Weiqing, AuthorWatson, Stanley J., AuthorWeickert, Thomas W., AuthorWitt, Stephanie H., AuthorXi, Simon, AuthorXu, Wei, AuthorYoung, Allan H., AuthorZandi, Peter, AuthorZhang, Peng, AuthorZollner, Sebastian, AuthorAdolfsson, Rolf, AuthorAgartz, Ingrid, AuthorAlda, Martin, AuthorBacklund, Lena, AuthorBaune, Bernhard T., AuthorBellivier, Frank, AuthorBerrettini, Wade H., AuthorBiernacka, Joanna M., AuthorBlackwood, Douglas H. R., AuthorBoehnke, Michael, AuthorBorglum, Anders D., AuthorCorvin, Aiden, AuthorCraddock, Nicholas, AuthorDaly, Mark J., AuthorDannlowski, Udo, AuthorEsko, Tonu, AuthorEtain, Bruno, AuthorFrye, Mark, AuthorFullerton, Janice M., AuthorGershon, Elliot S., AuthorGill, Michael, AuthorGoes, Fernando, AuthorGrigoroiu-Serbanescu, Maria, AuthorHauser, Joanna, AuthorHougaard, David M., AuthorHultman, Christina M., AuthorJones, Ian, AuthorJones, Lisa A., AuthorKahn, Rene S., AuthorKirov, George, AuthorLanden, Mikael, AuthorLeboyer, Marion, AuthorLewis, Cathryn M., AuthorLi, Qingqin S., AuthorLissowska, Jolanta, AuthorMartin, Nicholas G., AuthorMayoral, Fermin, AuthorMcElroy, Susan L., AuthorMcIntosh, Andrew M., AuthorMcMahon, Francis J., AuthorMelle, Ingrid, AuthorMetspalu, Andres, AuthorMitchell, Philip B., AuthorMorken, Gunnar, AuthorMors, Ole, AuthorMortensen, Preben Bo, AuthorMuller-Myhsok, Bertram1, AuthorMyers, Richard M., AuthorNeale, Benjamin M., AuthorNimgaonkar, Vishwajit, AuthorNordentoft, Merete, AuthorNoethen, Markus M., AuthorO'Donovan, Michael C., AuthorOedegaard, Ketil J., AuthorOwen, Michael J., AuthorPaciga, Sara A., AuthorPato, Carlos, AuthorPato, Michele T., AuthorPosthuma, Danielle, AuthorRamos-Quiroga, Josep Antoni, AuthorRibases, Marta, AuthorRietschel, Marcella, AuthorRouleau, Guy A., AuthorSchalling, Martin, AuthorSchofield, Peter R., AuthorSchulze, Thomas G., AuthorSerretti, Alessandro, AuthorSmoller, Jordan W., AuthorStefansson, Hreinn, AuthorStefansson, Kari, AuthorStordal, Eystein, AuthorSullivan, Patrick F., AuthorTurecki, Gustavo, AuthorVaaler, Arne E., AuthorVieta, Eduard, AuthorVincent, John B., AuthorWerge, Thomas, AuthorNurnberger, John I., AuthorWray, Naomi R., AuthorDi Florio, Arianna, AuthorEdenberg, Howard J., AuthorCichon, Sven, AuthorOphoff, Roel A., AuthorScott, Laura J., AuthorAndreassen, Ole A., AuthorKelsoe, John, AuthorSklar, Pamela, Author more..
1Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_1607137              


Free keywords: -
 Abstract: Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 x 10(-4) in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 x 10(-8)) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.


Language(s): eng - English
 Dates: 2019-05-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000466842000007
DOI: 10.1038/s41588-019-0397-8
 Degree: -



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Source 1

Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 51 (5) Sequence Number: - Start / End Page: 793 - + Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609