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  Resting-state dynamics as a neuromarker of dopamine administration in healthy female adults

Bellucci, G., Münte, T., & Park, S. (2019). Resting-state dynamics as a neuromarker of dopamine administration in healthy female adults. Journal of Psychopharmacology, 33(8), 955-964. doi:10.1177/0269881119855983.

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Bellucci, G1, Author              
Münte, TF, Author
Park, SQ, Author
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1External Organizations, ou_persistent22              

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 Abstract: BACKGROUND: Different neuromarkers of people's emotions, personality traits and behavioural performance have recently been identified. However, not much attention has been devoted to neuromarkers of neural responsiveness to drug administration. AIMS: We investigated the predictive neuromarkers of acute dopamine (DA) administration. METHODS: In a double-blind, within-subject study, we administrated a DA agonist (pramipexole) or placebo to 27 healthy female subjects. Using multivariate classification and prediction analyses, we examined whether dopaminergic modulations of task-free resting-state brain dynamics predict individual differences in pramipexole's modulation of facial attractiveness evaluations. RESULTS: Our results demonstrate that pramipexole's effects on brain dynamics could be successfully discriminated from resting-state functional connectivity (accuracy: 78.9%; p < 0.0001). On the behavioural level, pramipexole increased facial attractiveness evaluations (t(39) = 4.44; p < 0.0001). In particular, pramipexole administration enhanced connectivity strength of the cinguloopercular network (t(23) = 3.29; p = 0.003) and increased brain signal variability in subcortical and prefrontal brain areas (t(13) = 3.05, p = 0.009). Importantly, multivariate predictive models reveal that pramipexole-dependent modulation of resting-state dynamics predicted the increase of facial attractiveness evaluations after pramipexole (connectivity strength: standardized mean squared error, smse = 0.65; p = 0.0007; brain signal variability: smse = 0.94, p = 0.015). CONCLUSION: These results demonstrate that modulations of resting-state brain dynamics induced by a DA agonist predict drug-related effects on evaluation processes, providing a neuromarker of the neural responsiveness of specific brain networks to DA administration.

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 Dates: 2019-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1177/0269881119855983
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Title: Journal of Psychopharmacology
  Other : J. Psychopharmacol.
Source Genre: Journal
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Publ. Info: Oxford, UK : Sage Publications, Inc.
Pages: - Volume / Issue: 33 (8) Sequence Number: - Start / End Page: 955 - 964 Identifier: ISSN: 0269-8811
CoNE: https://pure.mpg.de/cone/journals/resource/954925501173